ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Associatively learned representations of taste outcomes activate taste-encoding neural ensembles in gustatory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 56 citations in OpenAlex.
- A brain stem circuit integrating reflexive and anticipatory salivation.Cell reports · 2026Article
- Contribution of Rat Insular Cortex to Stimulus-Guided Action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Targeted effects of ketamine on perceptual expectation during mediated learning in rats.Psychopharmacology · 2022Article
- Immunocytochemical and ultrastructural organization of the taste thalamus of the tree shrew (Tupaia belangeri).The Journal of comparative neurology · 2021Article
- Using internal memory representations in associative learning to study hallucination-like phenomenon.Neurobiology of learning and memory · 2020Review
- Probing for Conditioned Hallucinations Through Neural Activation in a Ketamine Mouse Model of Schizophrenia.Neuroscience bulletin · 2020Article
- Taste Processing: Insights from Animal Models.Molecules (Basel, Switzerland) · 2020Review
- Dynamic Representation of Taste-Related Decisions in the Gustatory Insular Cortex of Mice.Current biology : CB · 2020Article
- Cortical processing of chemosensory and hedonic features of taste in active licking mice.Journal of neurophysiology · 2020Article
- Mental imagery in animals: Learning, memory, and decision-making in the face of missing information.Learning & behavior · 2019Review
- Central taste anatomy and physiology.Handbook of clinical neurology · 2019Review
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- Associations and hallucinations in mice and men.Learning & behavior · 2018Article
- A greater tendency for representation mediated learning in a ketamine mouse model of schizophrenia.Behavioral neuroscience · 2018Article
- A neuronal basis for fear discrimination in the lateral amygdala.Nature communications · 2018Article
- Disconnection of basolateral amygdala and insular cortex disrupts conditioned approach in Pavlovian lever autoshaping.Neurobiology of learning and memory · 2018Article
- Article
- The Insula and Taste Learning.Frontiers in molecular neuroscience · 2017Review
- A gustocentric perspective to understanding primary sensory cortices.Current opinion in neurobiology · 2016Review
- Sensory Cortical Activity Is Related to the Selection of a Rhythmic Motor Action Pattern.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Through learning processes, cues associated with emotionally salient reinforcing outcomes can come to act as substitutes for the reinforcer itself. According to one account of this phenomenon, the predictive cue associatively elicits a representation of the expected outcome by reactivating cells responsible for encoding features of the primary reinforcer. We tested this hypothesis by examining the role of neural ensembles in gustatory cortex (GC) during receipt of gustatory stimuli (sucrose and water) and cues associated with those stimuli using the immediate early genes (IEGs) Arc and Homer1a. Because these plasticity-related IEGs are expressed in the neuronal nucleus 5 and 30 min, respectively, after salient events, we examined how individual neurons encoded these stimuli in two separate behavioral epochs. In experiment 1, we showed that tasting identical sucrose solutions, but not tasteless water, in the two epochs increased both IEG activity and the degree of overlap between neural ensembles in GC. In experiment 2, odor cues associated with sucrose, but not water, evoked potentiation of IEG activity in GC similar to sucrose itself. Surprisingly, lesions of the basolateral amygdala had minimal effects on associative encoding in GC. Finally, these associatively driven representations of sucrose appeared to be outcome specific, as neural ensembles that were activated by the sucrose-associated cue were also activated by sucrose itself. This degree of overlap between associative and primary taste activity at the ensemble level suggests that GC neurons encode important information about anticipated outcomes. Such representations may provide outcome-specific information for guiding goal-directed behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.