ArticleJournal of virology2010
Genetic analysis of the carboxy-terminal region of the hepatitis C virus core protein.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis.PloS one · 2017Article
- Identification of novel RNA secondary structures within the hepatitis C virus genome reveals a cooperative involvement in genome packaging.Scientific reports · 2016Article
- Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Hallmarks of hepatitis C virus in equine hepacivirus.Journal of virology · 2014Article
- HCV core protein and virus assembly: what we know without structures.Immunologic research · 2014Review
- Production and pathogenicity of hepatitis C virus core gene products.World journal of gastroenterology · 2014Review
- Unfolded protein response in hepatitis C virus infection.Frontiers in microbiology · 2014Review
- HCV core residues critical for infectivity are also involved in core-NS5A complex formation.PloS one · 2014Article
- Post-translational modifications of hepatitis C viral proteins and their biological significance.World journal of gastroenterology · 2013Review
- The identification of three sizes of core proteins during the establishment of persistent hepatitis C virus infection in vitro.Virologica Sinica · 2013Article
- Are trans-complementation systems suitable for hepatitis C virus life cycle studies?Journal of viral hepatitis · 2013Review
- Article
- Bidirectional lipid droplet velocities are controlled by differential binding strengths of HCV core DII protein.PloS one · 2013Article
- Structural analysis of hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase.Journal of virology · 2012Article
- Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.PLoS pathogens · 2012Article
- Morphogenesis of infectious hepatitis C virus particles.Frontiers in microbiology · 2012Article
- A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus.Journal of virology · 2011Article
- Trafficking of hepatitis C virus core protein during virus particle assembly.PLoS pathogens · 2011Article
- Production of hepatitis C virus lacking the envelope-encoding genes for single-cycle infection by providing homologous envelope proteins or vesicular stomatitis virus glycoproteins in trans.Journal of virology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Hepatitis C virus (HCV) is a liver-tropic pathogen with severe health consequences for infected individuals. Chronic HCV infection can progress to cirrhosis and hepatocellular carcinoma and is a leading indicator for liver transplantation. The HCV core protein is an essential component of the infectious virus particle, but many aspects of its role remain undefined. The C-terminal region of the core protein acts as a signal sequence for the E1 glycoprotein and undergoes dual processing events during infectious virus assembly. The exact C terminus of the mature, virion-associated core protein is not known. Here, we performed genetic analyses to map the essential determinants of the HCV core C-terminal region, as well as to define the minimal length of the protein that can function for infectious virus production in trans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.