ArticleJournal of leukocyte biology2010
Proteome bioprofiles distinguish between M1 priming and activation states in human macrophages.
Article in Journal of leukocyte biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Proteomic characterization of phagocytic primary human monocyte-derived macrophages.RSC chemical biology · 2022Article
- Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana.Retrovirology · 2022Article
- Deep neural network modeling identifies biomarkers of response to immune-checkpoint therapy.iScience · 2022Article
- Role of interferons in diabetic retinopathy.World journal of diabetes · 2021Review
- NRG4-ErbB4 signaling represses proinflammatory macrophage activity.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Unveiling the Physical and Functional Niches of FAM26F by Analyzing Its Subcellular Localization and Novel Interacting Partners.ACS omega · 2020Article
- Proteomic analysis reveals a protective role of specific macrophage subsets in liver repair.Scientific reports · 2019Article
- Programming and memory dynamics of innate leukocytes during tissue homeostasis and inflammation.Journal of leukocyte biology · 2017Review
- Pre-infection transcript levels of FAM26F in peripheral blood mononuclear cells inform about overall plasma viral load in acute and post-acute phase after simian immunodeficiency virus infection.The Journal of general virology · 2016Article
- T-helper-associated cytokines expression by peripheral blood mononuclear cells in patients with polypoidal choroidal vasculopathy and age-related macular degeneration.BMC ophthalmology · 2016Article
- Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera.Infection and immunity · 2015Article
- Rapid temporal dynamics of transcription, protein synthesis, and secretion during macrophage activation.Molecular & cellular proteomics : MCP · 2014Article
- Phenotypic diversity and emerging new tools to study macrophage activation in bacterial infectious diseases.Frontiers in immunology · 2014Review
- Immuno-modulatory Effect of IFN-gamma in AMD and its Role as a Possible Target for Therapy.Journal of clinical & experimental ophthalmology · 2013Article
- CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Macrophage activation is a dynamic process that results in diverse functional outcomes ranging from immunoregulation to inflammation. The proinflammatory, or M1, response is a complex, bimodal progression composed of a "prime," classically through IFN-gamma, and "trigger," such as LPS. To characterize the physiological response of M1 activation, a systems biology approach was applied to determine the intracellular proteome bioprofiles of IFN-gamma-and LPS-treated primary human macrophages. Our goal was to develop intracellular proteomic fingerprints to serve as novel correlates of macrophage priming and/or activation to augment the existing approaches of analyzing secreted cytokines and cell-surface protein expression. The majority of the proteome, approximately 78%, remained stable during activation, representing the core proteome. In contrast, three distinct patterns defined response proteomes: IFN-gamma-specific, LPS-specific, or IFN-gamma- and LPS-shared or M1-specific. Although steady-state expression levels of proteins involved in energy metabolism and immune response were increased during priming and triggering, changes in protein and fatty acid metabolism, signaling, and transport pathways were most apparent. Unique proteomic fingerprints distinguish among IFN-gamma-specific, LPS-specific, or M1-specific activation states and provide a clear molecular, archeological profile to infer recent history of cells, as well as correlates for chronic macrophage activation in health and disease.
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