ArticleProceedings. Biological sciences2010
A novel sex determination system in a close relative of the house mouse.
Article in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Multivariate Models of Animal Sex: Breaking Binaries Leads to a Better Understanding of Ecology and Evolution.Integrative and comparative biology · 2023Pooled it
- African pygmy mouse iPSCs as a model for in vitro embryogenesis, interspecies chimerism, and blastocyst complementation.Cell reports methods · 2026Article
- Evolution, Development, and the Incoherence of Sex: A Framework for Multiple Sex Concepts.Integrative and comparative biology · 2026Article
- Influence of Gonadal and Chromosomal Sex on the Brain Transcriptome in a Mouse Species with Natural Sex Reversal.Molecular biology and evolution · 2025Article
- X*Y females exhibit steeper reproductive senescence in the African pygmy mouse.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sex Chromosome Evolution: Hallmarks and Question Marks.Molecular biology and evolution · 2024Review
- Genotypic sex shapes maternal care in the African pygmy mouse,Proceedings. Biological sciences · 2023Article
- Polygenic sex determination in vertebrates - is there any such thing?Trends in genetics : TIG · 2023Review
- Polygenic sex determination produces modular sex polymorphism in an African cichlid fish.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- Dynamics of sex chromosome evolution in a rapid radiation of cichlid fishes.Science advances · 2021Article
- A brief review of vertebrate sex evolution with a pledge for integrative research: towards 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Review
- Identification of a novel sex determining chromosome in cichlid fishes that acts as XY or ZW in different lineages.Hydrobiologia · 2021Article
- Article
- Meiosis reveals the early steps in the evolution of a neo-XY sex chromosome pair in the African pygmy mouse Mus minutoides.PLoS genetics · 2020Article
- Complex Structure ofGenes · 2020Article
- Sex chromosome quadrivalents in oocytes of the African pygmy mouse Mus minutoides that harbors non-conventional sex chromosomes.Chromosoma · 2019Article
- X inactivation in a mammal species with three sex chromosomes.Chromosoma · 2018Article
- Haploid selection, sex ratio bias, and transitions between sex-determining systems.PLoS biology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therian mammals have an extremely conserved XX/XY sex determination system. A limited number of mammal species have, however, evolved to escape convention and present aberrant sex chromosome complements. In this study, we identified a new case of atypical sex determination in the African pygmy mouse Mus minutoides, a close evolutionary relative of the house mouse. The pygmy mouse is characterized by a very high proportion of XY females (74%, n = 27) from geographically widespread Southern and Eastern African populations. Sequencing of the high mobility group domain of the mammalian sex determining gene Sry, and karyological analyses using fluorescence in situ hybridization and G-banding data, suggest that the sex reversal is most probably not owing to a mutation of Sry, but rather to a chromosomal rearrangement on the X chromosome. In effect, two morphologically different X chromosomes were identified, one of which, designated X*, is invariably associated with sex-reversed females. The asterisk designates the still unknown mutation converting X*Y individuals into females. Although relatively still unexplored, such an atypical sex chromosome system offers a unique opportunity to unravel new genetic interactions involved in the initiation of sex determination in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.