ArticlePhysiology & behavior2010
Region-specific alteration in brain glutamate: possible relationship to risk-taking behavior.
Article in Physiology & behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
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- Prolonged Zaleplon Treatment Increases the Expression of Proteins Involved in GABAergic and Glutamatergic Signaling in the Rat Hippocampus.Brain sciences · 2023Article
- Modulating role of serotonergic signaling in sleep and memory.Pharmacological reports : PR · 2022Review
- Investigation of genetic loci shared between bipolar disorder and risk-taking propensity: potential implications for pharmacological interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- The effect of alcohol withdrawal syndrome severity on sleep, brain and cognition.Brain communications · 2020Article
- Acute and Chronic Sleep Deprivation-Related Changes in N-methyl-D-aspartate Receptor-Nitric Oxide Signalling in the Rat Cerebral Cortex with Reference to Aging and Brain Lateralization.International journal of molecular sciences · 2019Article
- Distinctive stress sensitivity and anxiety-like behavior in female mice: Strain differences matter.Neurobiology of stress · 2018Article
- Corticotropin releasing hormone and imaging, rethinking the stress axis.Nuclear medicine and biology · 2015Review
- Effect of diet on brain metabolites and behavior in spontaneously hypertensive rats.Behavioural brain research · 2014Article
- The impact of sleep loss on hippocampal function.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Review
- Neuropharmacology of Sleep and Wakefulness: 2012 Update.Sleep medicine clinics · 2012Article
- In vivo variation in metabotropic glutamate receptor subtype 5 binding using positron emission tomography and [11C]ABP688.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Article
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Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Risk-taking behaviors involve increased motor activity and reduced anxiety in humans. Total sleep deprivation (SD) in animals produces a similar change in motor and fear behaviors. Investigators studied region-specific brain levels of glutamate in rats after TSD, an animal model of risk-taking behavior. We investigated the effects of sleep deprivation on these behaviors and associated levels of brain glutamate. Compared to the controls, the sleep-deprived rats spent a significantly greater percentage of time in the open arms of the elevated plus maze (EPM), demonstrating reduced fear-like and increased risk-taking behaviors. Additionally, sleep deprivation was associated with a significant increase in glutamate levels in the hippocampus and thalamus. An inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the EPM and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. The role of sleep deprivation-induced changes in brain glutamate and its relationship to anxiety, fear, and posttraumatic stress disorder (PTSD) is discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.