ArticleMolecular and cellular endocrinology2010
Gene networks and the neuroendocrine regulation of puberty.
Article in Molecular and cellular endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 156 citations in OpenAlex.
- Neurotrophic Control of Puberty: From Molecular Signaling to Disorders of Pubertal Timing.Current issues in molecular biology · 2025Review
- A framework for identifying and prioritizing SNPs in genes of the hypothalamic- pituitary-gonadal axis in Guzerat cattle using amplicon-based NGS.BMC genomic data · 2025Article
- Metabolomics and transcriptomics analyses reveal the complex molecular mechanisms by which the hypothalamus regulates sexual development in female goats.BMC genomics · 2025Article
- Cardiovascular Risk in Pediatrics: A Dynamic Process during the First 1000 Days of Life.Pediatric reports · 2023Review
- Variations in gender identity and sexual orientation of university students.Sexual medicine · 2023Article
- A new DLK1 defect in a family with idiopathic central precocious puberty: elucidation of the male phenotype.Journal of endocrinological investigation · 2023Article
- Increased Incidence of Precocious Puberty in Girls During COVID-19 Pandemic: Early Indicator of the Upcoming Childhood Metabolic Syndrome Pandemic?Global pediatric health · 2022Article
- The Role of Pediatric Nutrition as a Modifiable Risk Factor for Precocious Puberty.Life (Basel, Switzerland) · 2021Review
- The Role of Fetal, Infant, and Childhood Nutrition in the Timing of Sexual Maturation.Nutrients · 2021Review
- Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression.Scientific reports · 2021Article
- Overexpression ofExperimental biology and medicine (Maywood, N.J.) · 2021Article
- Article
- Delayed Puberty-Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries.Endocrine reviews · 2019Review
- The analysis of endocrine disruptors in patients with central precocious puberty.BMC pediatrics · 2019Article
- Interdisciplinary Work Is Essential for Research on Puberty: Complexity and Dynamism in Action.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2019Review
- Postnatal Feeding With a Fat Rich Diet Induces Precocious Puberty Independent of Body Weight, Body Fat, and Leptin Levels in Female Mice.Frontiers in endocrinology · 2019Article
- The Genetic Basis of Delayed Puberty.Frontiers in endocrinology · 2019Review
- Genes underlying delayed puberty.Molecular and cellular endocrinology · 2018Review
- Article
- Characterization of the dynamic change of microRNA expression in mice hypothalamus during the time of female puberty.Genes & genomics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
A sustained increase in pulsatile release of gonadotrophin releasing hormone (GnRH) from the hypothalamus is an essential, final event that defines the initiation of mammalian puberty. This increase depends on coordinated changes in transsynaptic and glial-neuronal communication, consisting of activating neuronal and glial excitatory inputs to the GnRH neuronal network and the loss of transsynaptic inhibitory tone. It is now clear that the prevalent excitatory systems stimulating GnRH secretion involve a neuronal component consisting of excitatory amino acids (glutamate) and at least one peptide (kisspeptin), and a glial component that uses growth factors and small molecules for cell-cell signaling. GABAergic and opiatergic neurons provide transsynaptic inhibitory control to the system, but GABA neurons also exert direct excitatory effects on GnRH neurons. The molecular mechanisms that provide encompassing coordination to this cellular network are not known, but they appear to involve a host of functionally related genes hierarchically arranged. We envision that, as observed in other gene networks, the highest level of control in this network is provided by transcriptional regulators that, by directing expression of key subordinate genes, impose an integrative level of coordination to the neuronal and glial subsets involved in initiating the pubertal process. The use of high-throughput and gene manipulation approaches coupled to systems biology strategies should provide not only the experimental bases supporting this concept, but also unveil the existence of crucial components of network control not yet identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.