ArticleNeuron2009
Rapid axonal sprouting and pruning accompany functional reorganization in primary visual cortex.
Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A working model linking the psychopathology and pathophysiology of major depressive disorder - an umbrella review of neuroimaging studies and a conceptual framework.Molecular psychiatry · 2025Pooled it
- Pathway-dependent brain stimulation responses indicate motion processing integrity after stroke.Brain : a journal of neurology · 2025Trial
- Article
- Generating brain-wide connectome using synthetic axonal morphologies.Nature communications · 2025Article
- Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors.Nature communications · 2025Article
- Ventral posteromedial nucleus of the thalamus gates the spread of trigeminal neuropathic pain.The journal of headache and pain · 2024Article
- Induction of excitatory brain state governs plastic functional changes in visual cortical topology.Brain structure & function · 2024Review
- Chronic Adaptations in the Dorsal Horn Following a Cervical Spinal Cord Injury in Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Electrical stimulation of the cuneiform nucleus enhances the effects of rehabilitative training on locomotor recovery after incomplete spinal cord injury.Frontiers in neuroscience · 2024Article
- Tuina therapy promotes behavioral improvement and brain plasticity in rats with peripheral nerve injury and repair.Brain and behavior · 2023Article
- Cortical plasticity in central vision loss: Cortical thickness and neurite structure.Human brain mapping · 2023Article
- Stability and dynamics of dendritic spines in macaque prefrontal cortex.National science review · 2022Article
- Review
- Review
- Spike-Timing-Dependent Plasticity Mediated by Dopamine and its Role in Parkinson's Disease Pathophysiology.Frontiers in network physiology · 2022Review
- Growth rules for the repair of Asynchronous Irregular neuronal networks after peripheral lesions.PLoS computational biology · 2021Article
- Long-Term Desynchronization by Coordinated Reset Stimulation in a Neural Network Model With Synaptic and Structural Plasticity.Frontiers in physiology · 2021Article
- Regulation of auditory plasticity during critical periods and following hearing loss.Hearing research · 2020Review
- Altered Sensitivity to Motion of Area MT Neurons Following Long-Term V1 Lesions.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- A generative growth model for thalamocortical axonal branching in primary visual cortex.PLoS computational biology · 2020Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The functional architecture of adult cerebral cortex retains a capacity for experience-dependent change. This is seen following focal binocular lesions, which induce rapid changes in receptive field size and position. To follow the dynamics of the circuitry underlying these changes, we imaged the intrinsic long-range horizontal connections within the lesion projection zone (LPZ) in adult macaque primary visual cortex. To image the same axons over time, we combined viral vector-mediated EGFP transfer and two-photon microscopy. The lesion triggered, within the first week, an approximately 2-fold outgrowth of axons toward the center of the LPZ. Over the subsequent month, axonal density declined due to a parallel process of pruning and sprouting but maintained a net increase relative to prelesion levels. The rate of turnover of axonal boutons also increased. The axonal restructuring recapitulates the pattern of exuberance and pruning seen in early development and correlates well with the functional changes following retinal lesions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.