Trial reportNeuron2009
Altering cortical connectivity: remediation-induced changes in the white matter of poor readers.
Trial report in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Emerging technologies and neuroscience-based approaches in dyslexia: a narrative review toward integrative and personalized solutions.Frontiers in human neuroscience · 2025Pooled it
- Reading intervention and neuroplasticity: A systematic review and meta-analysis of brain changes associated with reading intervention.Neuroscience and biobehavioral reviews · 2022Pooled it
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- Training-Induced Neural Plasticity in Youth: A Systematic Review of Structural and Functional MRI Studies.Frontiers in human neuroscience · 2020Pooled it
- Altered thalamo–cortical and occipital–parietal– temporal–frontal white matter connections in patients with anorexia and bulimia nervosa: a systematic review of diffusion tensor imaging studiesJournal of psychiatry & neuroscience : JPN · 2019Pooled it
- Neuroimaging of reading intervention: a systematic review and activation likelihood estimate meta-analysis.PloS one · 2014Pooled it
- Structural abnormalities in the dyslexic brain: a meta-analysis of voxel-based morphometry studies.Human brain mapping · 2013Pooled it
- Assessing white matter plasticity in a randomized controlled trial of early literacy training in preschoolers.PloS one · 2025Trial
- Training-induced improvements in postural control are accompanied by alterations in cerebellar white matter in brain injured patients.NeuroImage. Clinical · 2015Trial
- Memory training impacts short-term changes in aging white matter: a longitudinal diffusion tensor imaging study.Human brain mapping · 2012Trial
- Differences in integrity of white matter and changes with training in spelling impaired children: a diffusion tensor imaging study.Brain structure & function · 2012Trial
- Developmental Reading-Network Reorganization in Developmental Dyslexia: A Neuroplasticity Framework.Brain sciences · 2026Review
- White Matter Diffusivity Predicts Change in Sight Word Reading Following Continuous Theta Burst Stimulation to the Left Temporal Parietal Junction.Neurobiology of language (Cambridge, Mass.) · 2026Article
- White Matter Networks of Phonological Awareness in Chinese Readers.Brain and behavior · 2025Article
- Impairment of Oligodendroglial Lineage Cells: An Important Player in the Pathogenesis of Psychiatric Disorders.Advances in neurobiology · 2025Review
- Listening to mom in the neonatal intensive care unit: a randomized trial of increased maternal speech exposure on white matter connectivity in infants born preterm.Frontiers in human neuroscience · 2025Article
- White matter and literacy: A dynamic system in flux.Developmental cognitive neuroscience · 2024Article
- White matter microstructural plasticity associated with educational intervention in reading disability.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- An Overview on Electrophysiological and Neuroimaging Findings in Dyslexia.Iranian journal of psychiatry · 2023Article
- Introducing the Neuroplastic Narrative: a non-pathologizing biological foundation for trauma-informed and adverse childhood experience aware approaches.Frontiers in psychiatry · 2023Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Neuroimaging studies using diffusion tensor imaging (DTI) have revealed regions of cerebral white matter with decreased microstructural organization (lowerfractional anisotropy or FA) among poor readers. We examined whether 100 hr of intensive remedial instruction affected the white matter of 8- to 10-year-old poor readers. Prior to instruction, poor readers had significantly lower FA than good readers in a region of the left anterior centrum semiovale. The instruction resulted in a change in white matter (significantly increased FA), and in the very same region. The FA increase was correlated with a decrease in radial diffusivity (but not with a change in axial diffusivity), suggesting that myelination had increased. Furthermore, the FA increase was correlated with improvement in phonological decoding ability, clarifying the cognitive locus of the effect. The results demonstrate the capability of a behavioral intervention to bring about a positive change in cortico-cortical white matter tracts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.