ArticleImmunity2009
T cell receptor CDR3 sequence but not recognition characteristics distinguish autoreactive effector and Foxp3(+) regulatory T cells.
Article in Immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells.The Journal of experimental medicine · 2020Article
- Regulatory T Cells: the Many Faces of Foxp3.Journal of clinical immunology · 2019Review
- A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3Nature immunology · 2019Article
- High self-reactivity drives T-bet and potentiates Treg function in tissue-specific autoimmunity.JCI insight · 2018Article
- CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity.Frontiers in immunology · 2017Article
- Autoimmune susceptibility imposed by public TCRβ chains.Scientific reports · 2016Article
- Hydrophobic CDR3 residues promote the development of self-reactive T cells.Nature immunology · 2016Article
- Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen.Immunological reviews · 2016Review
- Conventional and Regulatory CD4+ T Cells That Share Identical TCRs Are Derived from Common Clones.PloS one · 2016Article
- FOXP3+ regulatory T cells and their functional regulation.Cellular & molecular immunology · 2015Review
- Regulatory T cells control diabetes without compromising acute anti-viral defense.Clinical immunology (Orlando, Fla.) · 2014Article
- Once a Treg, always a Treg?Immunological reviews · 2014Review
- Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis.European journal of immunology · 2013Article
- CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Generation and function of induced regulatory T cells.Frontiers in immunology · 2013Article
- Treg cells, life history, and diversity.Cold Spring Harbor perspectives in biology · 2012Review
- Context and location dependence of adaptive Foxp3(+) regulatory T cell formation during immunopathological conditions.Cellular immunology · 2012Review
- Nature and nurture in Foxp3(+) regulatory T cell development, stability, and function.Human immunology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3)(+) regulatory T (Treg) and conventional T (Tconv) cell populations active at sites of autoimmune pathology are not well characterized. To evaluate this, we combined global repertoire analyses and functional assessments of isolated T cell receptors (TCR) from TCRalpha retrogenic mice with autoimmune encephalomyelitis. Treg and Tconv cell TCR repertoires were distinct, and autoantigen-specific Treg and Tconv cells were enriched in diseased tissue. Autoantigen sensitivity and fine specificity of these cells intersected, implying that differences in responsiveness were not responsible for lineage specification. Notably, autoreactive Treg and Tconv cells could be fully distinguished by an acidic versus aliphatic variation at a single TCR CDR3 residue. Our results imply that ontogenically distinct Treg and Tconv cell repertoires with convergent specificities for autoantigen respond during autoimmunity and argue against more than limited plasticity between Treg and Tconv cells during autoimmune inflammation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.