ArticleAtherosclerosis2010
Osteocalcin positive mononuclear cells are associated with the severity of aortic calcification.
Article in Atherosclerosis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Circulating osteogenic progenitors and osteoclast precursors are associated with long-term glycemic control, sex steroids, and visceral adipose tissue in men with type 2 diabetes mellitus.Frontiers in endocrinology · 2022Trial
- Roles of vitamin K‑dependent protein in biomineralization (Review).International journal of molecular medicine · 2024Review
- Osteocalcin-expressing endothelial progenitor cells and serum osteocalcin forms are independent biomarkers of coronary atherosclerotic disease severity in male and female patients.Journal of endocrinological investigation · 2022Article
- Development and validation of a new method to isolate, expand, and differentiate circulating osteogenic precursor (COP) cells.Bone reports · 2021Article
- Osteocalcin, Osteopontin and RUNX2 Expression in Patients' Leucocytes with Arteriosclerosis.Diseases (Basel, Switzerland) · 2021Article
- Association between Serum Osteocalcin Levels and Metabolic Syndrome according to the Menopausal Status of Korean Women.Journal of Korean medical science · 2021Article
- Circulating osteogenic precursor cells: Building bone from blood.EBioMedicine · 2019Review
- Potential Role for Osteocalcin in the Development of Atherosclerosis and Blood Vessel Disease.Nutrients · 2018Review
- Harnessing Endogenous Cellular Mechanisms for Bone Repair.Frontiers in bioengineering and biotechnology · 2017Review
- Diagnostic performance of bone metabolic indexes for the detection of stroke.Saudi medical journal · 2017Article
- Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis.Frontiers in endocrinology · 2017Article
- Consolidated and emerging inflammatory markers in coronary artery disease.World journal of experimental medicine · 2015Review
- Arterial calcification: Finger-pointing at resident and circulating stem cells.World journal of stem cells · 2014Review
- Mesenchymal stem cells recruited by active TGFβ contribute to osteogenic vascular calcification.Stem cells and development · 2014Article
- Association of bone turnover markers with mortality in men referred to coronary angiography.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers.The Journal of clinical endocrinology and metabolism · 2012Article
- Role of circulating osteogenic progenitor cells in calcific aortic stenosis.Journal of the American College of Cardiology · 2012Article
- Emerging role of circulating calcifying cells in the bone-vascular axis.Circulation · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo assess the association of circulating bone marrow-derived osteo-progenitors with vascular calcification in mouse models and patients with peripheral artery disease.
methodsWe estimated the percentage of circulating mononuclear cells expressing osteocalcin in 2 mouse models of aortic calcification developed in osteoprotegerin-deficient mice (OPG(-/-)) using flow cytometry. Aortic calcification was assessed in mice principally by a bioassay of harvested aortas. In patients with peripheral artery disease osteocalcin-positive cells (estimated by flow cytometry) were related to aortic calcification volume assessed from computed tomography.
resultsThe amount of extractable aortic calcium was increased in both mouse models used in comparison to controls. The percentage of circulating mononuclear cells expressing osteocalcin was correlated to the amount of extractable aortic calcium in male (r=0.525, p=0.02) and female OPG(-/-) (r=0.564, p=0.02) mice and also in animals in which calcification was accelerated using calcitriol (r=0.64, p=0.01). Patients with more severe aortic calcification had a greater percentage of circulating OCN(+) MNCs (median 4.07%, IQR 3.76-4.39, n=12) than those with less severe aortic calcification (median 3.10%, IQR 2.32-3.60, n=11, p=0.05).
conclusionsThis study demonstrates that aortic calcification can be robustly quantified in 2 mouse models. In these models and patients with peripheral artery disease circulating osteocalcin positive mononuclear cells are associated with the severity of aortic calcification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.