Evidence map›Paper›PMID 20004787›Full record

ArticleThe Journal of allergy and clinical immunology2009

Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5(-) T(H)2 responses.

Calman Prussin, Joohee Lee, Barbara Foster

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00557895 (Evaluation and Long Term Follow-up of Patients With Allergic and Inflammatory Disorders), which is not on this map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00557895 terminatednot on this map

Evaluation and Long Term Follow-up of Patients With Allergic and Inflammatory Disorders

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran1996 to 2019Enrolled288ConditionsAllergy, Asthma, Allergic Rhinitis, Mastocytosis
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 134 citations in OpenAlex.

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  11. Distinct CRTH2+CD161+ (peTh2) memory CD4+ T-cell cytokine profiles in food allergy and eosinophilic gastrointestinal disorders.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023
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  20. Pathophysiology of Non-IgE-Mediated Food Allergy.ImmunoTargets and therapy · 2021
    Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Calman PrussinLaboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1881, USA. cprussin@niaid.nih.gov
Joohee Lee
Barbara Foster
National Institutes of Health · USNational Institute of Allergy and Infectious Diseases · US

Funding

T Cell Pathogenesis of Food AllergyZIAAI000993 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI PRUSSIN, CALMAN · 2009 to 2015
$4.1M
Memory T Cell Responses to Food AllergyZ01AI000993 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI PRUSSIN, CALMAN · 2007 to 2008
$808k
Intramural NIH HHS Z01 AI000993Intramural NIH HHS ZIA AI000993
6 · The paper itself

Abstract

backgroundBoth anaphylactic food allergy and eosinophil-associated gastrointestinal disorders are associated with T(H)2 responses and food-specific IgE, yet they have very different clinical presentations.

objectiveTo determine whether the clinical differences between anaphylactic food allergy and eosinophil-associated gastrointestinal disorders are reflected in different T(H)2 responses to foods.

methodsSubjects with peanut allergy (PA), subjects with allergic eosinophilic gastroenteritis (AEG), and nonatopic subjects were enrolled. Antigen-specific IL-4, IL-5, IFN-gamma, and TNF T-cell responses to peanut, soy, and shrimp were measured by using intracellular cytokine staining and polychromatic flow cytometry.

resultsTwo distinct subpopulations of T(H)2 cells were found: IL-5+ T(H)2 (IL-4+, IL-5+) and IL-5(-) T(H)2 (IL-4+, IL-5(-)) cells. Peanut-specific IL-5+ T(H)2 cells were present at a 20-fold greater frequency in AEG versus PA (81 vs 4 per 10(6) CD4 cells; P = .05), whereas there were similar frequencies of IL-5(-) T(H)2 cells (67 vs 41 per 10(6)). For all foods, IL-5+ T(H)2 cells accounted for a significantly greater fraction of the antigen-specific cells in AEG relative to PA (29% vs 4%; P < .0001). In PA but not AEG, IL-5(-) T(H)2 responses to peanut were highly correlated with peanut-specific IgE (r = 0.87 vs 0.55, respectively). All subject groups elicited similar very low-magnitude T(H)1 responses to food antigens.

conclusionT(H)2 responses are composed of 2 subpopulations: IL-5+ T(H)2 and IL-5(-) T(H)2 cells. IL-5+ T(H)2 food allergen-specific T cells are singularly associated with AEG, whereas PA is associated with a dominant IL-5(-) T(H)2 response. These results suggest heterogeneity within the T(H)2 cytokine response, with different T(H)2 responses alternatively favoring IgE-mediated or eosinophil-dominant immunopathology.

Indexed as

AdolescentAdultAllergensArachisEosinophilsFemaleGastroenteritisHumansInterferon-gammaInterleukin-4Interleukin-5MaleMiddle AgedPeanut HypersensitivityTh2 CellsT-Lymphocyte SubsetsAllergensInterferon-gammaInterleukin-4Interleukin-5Tumor Necrosis Factor-alpha

Identifiers

PMID20004787
PMCPMC2994258
OpenAlexW2147750411

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.