Evidence map›Paper›PMID 20004512›Full record

ReviewCancer letters2010

MicroRNA in pancreatic cancer: pathological, diagnostic and therapeutic implications.

Satyanarayana Rachagani, Sushil Kumar, Surinder K Batra

Abstract readReview
In one paragraph

Review in Cancer letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 91 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Potential role of microRNAs in pancreatic cancer manifestation: a review.Journal of the Egyptian National Cancer Institute · 2022
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Molecular Aberrations in Periampullary Carcinoma.Indian journal of surgical oncology · 2017
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Advances in miRNA-Mediated Mucin Regulation.Current pharmacology reports · 2015
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Satyanarayana RachaganiDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Sushil Kumar
Surinder K Batra
University of Nebraska Medical Center · US

Funding

Early Diagnosis of Pancreatic CancerU01CA111294 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K., HOLLINGSWORTH, MICHAEL A. · 2004 to 2015
$7.1M
MOLECULAR STUDIES ON MUC4 MUCIN GENER01CA078590 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K. · 1998 to 2011
$2.5M
Smoking and pancreatic cancerR01CA133774 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K. · 2008 to 2012
$1.8M
Molecular Markers for the Diagnosis of Pancreatic CancerR01CA131944 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K. · 2008 to 2012
$1.5M
NCI NIH HHS CA111294NCI NIH HHS CA131944NCI NIH HHS CA133774NCI NIH HHS CA78590NCI NIH HHS R01 CA078590NCI NIH HHS R01 CA131944NCI NIH HHS R01 CA133774NCI NIH HHS U01 CA111294
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are a group of small non-coding RNA molecules of 17-25 nucleotides (nt) in length, predicted to control the activity of about 30% of all protein-coding genes in mammals. Altered expressions of miRNAs are reported in various cancers and may associate with cancer pathogenesis, apoptosis, and cell growth, thereby functioning as either tumor suppressors or oncogenes. Recent reports showed that deregulation of miRNA contribute to tumor development and progression and hence, have diagnostic and prognostic value in several human malignancies. This review discusses the current status of miRNA in pancreatic cancer development, progression, diagnosis, and therapy.

Indexed as

Biomarkers, TumorCell Line, TumorGene Expression Regulation, NeoplasticHumansMicroRNAsPancreatic NeoplasmsPrognosisProtein FoldingBiomarkers, TumorMicroRNAs

Identifiers

PMID20004512
PMCPMC3229224
OpenAlexW2160282097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.