ArticleFertility and sterility2010
An aromatase polymorphism modulates the relationship between weight and estradiol levels in obese men.
Article in Fertility and sterility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts.Nutrients · 2024Review
- Diet-induced obesity impairs spermatogenesis: the critical role of NLRP3 in Sertoli cells.Inflammation and regeneration · 2022Article
- Inositols: From Established Knowledge to Novel Approaches.International journal of molecular sciences · 2021Review
- Irisin alleviates obesity-related spermatogenesis dysfunction via the regulation of the AMPKα signalling pathway.Reproductive biology and endocrinology : RB&E · 2021Article
- Diet-induced obesity impairs spermatogenesis: a potential role for autophagy.Scientific reports · 2017Article
- Estrogens and Body Weight Regulation in Men.Advances in experimental medicine and biology · 2017Review
- Hormone-Based Treatments in Subfertile Males.Current urology reports · 2016Review
- [Gender Obesity Report--Influence of obesity on Reproduction and Pregnancy].Wiener medizinische Wochenschrift (1946) · 2016Review
- Testosterone-induced effects on lipids and inflammation.Mediators of inflammation · 2013Review
- Updates on the relation of weight excess and reproductive function in men: sleep apnea as a new area of interest.Asian journal of andrology · 2012Review
- Obesity: modern man's fertility nemesis.Asian journal of andrology · 2010Review
- Clinical management of infertile men with nonobstructive azoospermia.Asian journal of andrologyReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo describe the influence of the TTTA aromatase polymorphism (TTTAn) on the relation between obesity and plasma estradiol (E(2)) in obese men.
designA 2-year cohort study.
settingClinical research center. PATIENT(S): Severely obese men (31 who had had gastric bypass surgery and 118 controls). INTERVENTION(S): Men were genotyped for the TTTAn CYP19A1 polymorphism. Anthropomorphic measures, plasma E(2), and other hormonal levels were determined at baseline and 2-year follow-up. MAIN OUTCOMES MEASURE(S): Relationships between weight and changes in weight and plasma E(2) were examined in relation to the TTTAn polymorphism. RESULT(S): The mean age was 46.5 ± 10.82 years, and mean body mass index was 47.1 ± 8.46 kg/m(2). The most common repeats were 7 and 11. TTTAn number did not correlate with plasma E(2) in the univariate analysis. When patients were stratified per weight group, the correlation between plasma E(2) and weight was seen only among men with a higher TTTA repeat at baseline and 2 years. Similarly, only men with higher TTTA exhibited reduced E(2) levels after weight loss. CONCLUSION(S): A higher TTTA repeat is associated with a strengthened relationship between obesity and E(2). The well-established effect of increased weight on plasma E(2) appears to be absent in men with low TTTA numbers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.