ArticleNeurotoxicology and teratology
Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Evaluation of developmental toxicity of chlorpyrifos through new approach methodologies: a systematic review.Archives of toxicology · 2025Pooled it
- Bacterial Diversity in Leaf-Cutter Ant Species: Host-Microbe Interactions and Environmental Effects.Neotropical entomology · 2026Article
- Determinants of urinary dialkyl phosphate metabolites in midlife women: the Study of Women's Health Across the Nation Multi-Pollutant Study (SWAN-MPS).Journal of exposure science & environmental epidemiology · 2025Article
- Effect of Gestational Pesticide Exposure on the Child's Respiratory System: A Narrative Review.International journal of environmental research and public health · 2022Review
- Prenatal exposure to organophosphate pesticides and risk-taking behaviors in early adulthood.Environmental health : a global access science source · 2022Article
- Potential Protective Effect of Vitamin C on Qunalphos-Induced Cardiac Toxicity: Histological and Tissue Biomarker Assay.Biomedicines · 2021Article
- Gestational Exposure to Organophosphate Pesticides and Longitudinally Assessed Behaviors Related to Attention-Deficit/Hyperactivity Disorder and Executive Function.American journal of epidemiology · 2021Article
- Gene-Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres.Environmental health perspectives · 2021Article
- Associations between pesticide mixtures applied near home during pregnancy and early childhood with adolescent behavioral and emotional problems in the CHAMACOS study.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Oxidative stress, hematological and biochemical alterations induced by sub-acute exposure to fipronil (COACHEnvironmental science and pollution research international · 2020Article
- Organophosphate pesticide metabolite concentrations in urine during pregnancy and offspring attention-deficit hyperactivity disorder and autistic traits.Environment international · 2019Article
- Determinants of organophosphate pesticide exposure in pregnant women: A population-based cohort study in the Netherlands.International journal of hygiene and environmental health · 2018Article
- Clinical effects of chemical exposures on mitochondrial function.Toxicology · 2017Review
- Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms.Journal of neurochemistry · 2017Review
- Non-cytotoxic Concentration of Cisplatin Decreases Neuroplasticity-Related Proteins and Neurite Outgrowth Without Affecting the Expression of NGF in PC12 Cells.Neurochemical research · 2016Article
- Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors.Toxicology · 2015Article
- Prenatal organophosphates exposure alternates the cleavage plane orientation of apical neural progenitor in developing neocortex.PloS one · 2014Article
- Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community.Environmental research · 2012Article
- Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants.Brain research bulletin · 2010Article
- BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells.Neurotoxicology and teratologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Oxidative stress has been hypothesized to provide a mechanism by which apparently unrelated chemicals can nevertheless produce similar developmental neurotoxic outcomes. We used differentiating PC12 cells to compare the effects of agents from four different classes and then to evaluate antioxidant amelioration: fipronil, perfluorooctanesulfonamide (PFOSA), dieldrin and chlorpyrifos. The rank order for lipid peroxidation corresponded to the ability to evoke cell loss: fipronil>PFOSA>dieldrin>chlorpyrifos. The same sequence was found for an index of cell enlargement (protein/DNA ratio) but the effects on neurite outgrowth (membrane/total protein) diverged, with fipronil producing a decrease and PFOSA an increase. Cotreatment with antioxidants reduced (ascorbate) or eliminated (Vitamin E) lipid peroxidation caused by each of the agents but failed to protect against cell loss, with the sole exception of chlorpyrifos, for which we earlier showed partial protection by Vitamin E; addition of higher NGF concentrations protected neither against oxidative stress nor cell loss. Despite the failure to prevent cell loss, ascorbate protected the cells from the effects of PFOSA on neuritic outgrowth; NGF, and to a lesser extent, ascorbate, offset the effects of fipronil on both cell enlargement and neuritogenesis. At the same time, the ameliorant treatments also worsened some of the other toxicant effects. Our results point out the problems in concluding that, just because a neurotoxicant produces oxidative stress, antioxidant therapy will be effective in preventing damage. Instead, additional mechanisms for each agent may provide alternative routes to neurotoxicity, or may be additive or synergistic with oxidative stress.
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