ArticleJournal of molecular biology2010
Light activation of rhodopsin: insights from molecular dynamics simulations guided by solid-state NMR distance restraints.
Article in Journal of molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism.International journal of molecular sciences · 2023Article
- Rhodopsins: An Excitingly Versatile Protein Species for Research, Development and Creative Engineering.Frontiers in chemistry · 2022Review
- Quantum Mechanical and Molecular Mechanics Modeling of Membrane-Embedded Rhodopsins.The Journal of membrane biology · 2019Review
- Implications of short time scale dynamics on long time processes.Structural dynamics (Melville, N.Y.) · 2017Review
- New views on phototransduction from atomic force microscopy and single molecule force spectroscopy on native rods.Scientific reports · 2017Article
- Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation.Nature communications · 2016Article
- Retinal Conformation Changes Rhodopsin's Dynamic Ensemble.Biophysical journal · 2015Article
- Structural approaches to understanding retinal proteins needed for vision.Current opinion in cell biology · 2014Review
- Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures.Biochemistry · 2014Article
- Deconstructing activation events in rhodopsin.Journal of the American Chemical Society · 2013Article
- Retinal conformation governs pKa of protonated Schiff base in rhodopsin activation.Journal of the American Chemical Society · 2013Article
- Thermostabilization of the β1-adrenergic receptor correlates with increased entropy of the inactive state.The journal of physical chemistry. B · 2013Article
- Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop.The Journal of biological chemistry · 2012Article
- Structural transitions of transmembrane helix 6 in the formation of metarhodopsin I.The journal of physical chemistry. B · 2012Article
- Structural intermediates during α-synuclein fibrillogenesis on phospholipid vesicles.Journal of the American Chemical Society · 2012Article
- Action of molecular switches in GPCRs--theoretical and experimental studies.Current medicinal chemistry · 2012Review
- The significance of G protein-coupled receptor crystallography for drug discovery.Pharmacological reviews · 2011Review
- Light activation of the isomerization and deprotonation of the protonated Schiff base retinal.Journal of molecular modeling · 2011Article
- Identification of essential cannabinoid-binding domains: structural insights into early dynamic events in receptor activation.The Journal of biological chemistry · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Structural restraints provided by solid-state NMR measurements of the metarhodopsin II intermediate are combined with molecular dynamics simulations to help visualize structural changes in the light activation of rhodopsin. Since the timescale for the formation of the metarhodopsin II intermediate (>1 ms) is beyond that readily accessible by molecular dynamics, we use NMR distance restraints derived from 13C dipolar recoupling measurements to guide the simulations. The simulations yield a working model for how photoisomerization of the 11-cis retinylidene chromophore bound within the interior of rhodopsin is coupled to transmembrane helix motion and receptor activation. The mechanism of activation that emerges is that multiple switches on the extracellular (or intradiscal) side of rhodopsin trigger structural changes that converge to disrupt the ionic lock between helices H3 and H6 on the intracellular side of the receptor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.