ArticleProceedings of the National Academy of Sciences of the United States of America1991
Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 106 citations in OpenAlex.
- PKA knockdown enhances cell killing in response to radiation and androgen deprivation.International journal of cancer · 2011Article
- Cyclic nucleotides and phosphodiesterases in monocytic differentiation.Handbook of experimental pharmacology · 2011Review
- Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit.BMC cell biology · 2008Article
- Gene expression profiling during all-trans retinoic acid-induced cell differentiation of acute promyelocytic leukemia cells.The Journal of molecular diagnostics : JMD · 2003Article
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- Antisense DNAs as multisite genomic modulators identified by DNA microarray.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
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- Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase.Molecular and cellular biology · 1998Article
- Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotide targeting protein kinase A.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Point mutation of the autophosphorylation site or in the nuclear location signal causes protein kinase A RII beta regulatory subunit to lose its ability to revert transformed fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Downregulation of mdr-1 expression by 8-Cl-cAMP in multidrug resistant MCF-7 human breast cancer cells.The Journal of clinical investigation · 1995Article
- A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth.Nature medicine · 1995Article
- Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis.The EMBO journal · 1995Article
- Selective inhibition of adenylate cyclase in bovine cortex by quinones: a novel cellular substrate for quinone cytotoxicity.The Biochemical journal · 1994Article
- Transcriptional regulation of multidrug resistance in breast cancer.Breast cancer research and treatment · 1994Review
- Early events of human T lymphocyte activation are associated with type I protein kinase A activity.The Journal of clinical investigation · 1993Article
- Differential expression of cAMP-kinase subunits is correlated with growth in rat mammary carcinomas and uterus.British journal of cancer · 1992Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A marked decrease in the type I cAMP-dependent protein kinase regulatory subunit (RI alpha) and an increase in the type II protein kinase regulatory subunit (RII beta) correlate with growth inhibition and differentiation induced in a variety of types of human cancer cells, in vitro and in vivo, by site-selective cAMP analogs. To directly determine whether RI alpha is a growth-inducing protein essential for neoplastic cell growth, human HL-60 promyelocytic leukemia cells were exposed to 21-mer RI alpha antisense oligodeoxynucleotide, and the effects on cell replication and differentiation were examined. The RI alpha antisense oligomer brought about growth inhibition and monocytic differentiation, bypassing the effects of an exogenous cAMP analog. These effects of RI alpha antisense oligodeoxynucleotide correlated with a decrease in RI alpha receptor and an increase in RII beta receptor level. The growth inhibition and differentiation were abolished, however, when these cells were exposed simultaneously to both RI alpha and RII beta antisense oligodeoxynucleotides. The RII beta antisense oligodeoxynucleotide alone has been previously shown to specifically block the differentiation inducible by cAMP analogs. These results provide direct evidence that RI alpha cAMP receptor plays a critical role in neoplastic cell growth and that cAMP receptor isoforms display specific roles in cAMP regulation of cell growth and differentiation.
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