ArticleDynamic medicine : DM2009
The reproducibility of measurements of intramuscular magnesium concentrations and muscle oxidative capacity using 31P MRS.
Article in Dynamic medicine : DM, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pooled it
- Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using (31)P magnetic resonance spectroscopy.Scientific reports · 2016Trial
- Trial
- Ankle-Brachial Index and Energy Production in People Without Peripheral Artery Disease: The BLSA.Journal of the American Heart Association · 2022Article
- Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency.Nutrients · 2021Review
- Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla.Magnetic resonance in medicine · 2021Article
- Nanothermometry Reveals Calcium-Induced Remodeling of Myosin.Nano letters · 2018Article
- Tai Chi Improves Brain Metabolism and Muscle Energetics in Older Adults.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
- Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low-Normal Ankle-Brachial Index.Journal of the American Heart Association · 2017Article
- A low-cost Mr compatible ergometer to assess post-exercise phosphocreatine recovery kinetics.Magma (New York, N.Y.) · 2017Article
- Muscle strength mediates the relationship between mitochondrial energetics and walking performance.Aging cell · 2017Article
- Evaluation of a NewConcepts in magnetic resonance. Part B, Magnetic resonance engineering · 2013Article
- Methods for assessing mitochondrial function in diabetes.Diabetes · 2013Review
- Noninvasive evaluation of skeletal muscle mitochondrial capacity with near-infrared spectroscopy: correcting for blood volume changes.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men.PloS one · 2012Article
- Measurement of human skeletal muscle oxidative capacity by 31P-MR spectroscopy: a cross-validation with in vitro measurements.Journal of magnetic resonance imaging : JMRI · 2011Article
- Skeletal muscle metabolism in individuals with spinal cord injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Mitochondrial metabolic function assessed in vivo and in vitro.Current opinion in clinical nutrition and metabolic care · 2010Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
31P magnetic resonance spectroscopy (31P MRS) has been used to measure intramuscular magnesium concentrations and muscle metabolism. Abnormal intramuscular magnesium has been reported in several patient populations with suspected metabolic disorders. The purpose of this study was to evaluate our ability to measure intramuscular magnesium and muscle metabolism in the quadriceps muscles of healthy subjects, and to test whether these measurements were influenced by prior exercise. Twelve normal, healthy male volunteers were tested in a 3 Tesla magnet on four separate days. Resting [Mg2+] was calculated from the heights and frequency shifts of the phosphate, phosphocreatine and ATP peaks. Phosphocreatine (PCr) recovery kinetics were measured after 30-39 second bouts of isometric exercise. Thirty minutes prior to the 3rd test session the subjects completed a 2 hour treadmill walk at 40-60% of heart rate reserve. Resting [Mg2+] averaged 0.388 mM and had an interclass correlation coefficient between days (ICC) of 0.352. The mean end exercise PCr was 47.6% and the mean end exercise pH was 6.97. PCr recovery averaged 39 seconds (p = 0.892) and had an ICC of 0.819. Prior long duration exercise did not produce significant alterations in either PCr recovery kinetics or intracellular magnesium levels (p = 0.440). In conclusion, the reproducibility of Resting [Mg2+] was less than that of PCr recovery measurements, and may reflect the sensitivity of these measurements to phasing errors. In addition, prior exercise is unlikely to alter measurements of resting metabolites or muscle metabolism suggesting that rigorous control of physical activity prior to metabolic testing is unnecessary.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.