Evidence map›Paper›PMID 20003428›Full record

ArticleBMC genetics2009

Estimates of linkage disequilibrium and effective population size in rainbow trout.

Caird E Rexroad, Roger L Vallejo

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Article in BMC genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

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22citing papers in PubMed
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3 · Its place in the literature

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22 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Caird E RexroadUSDA/ARS National Center for Cool and Cold Water Aquaculture, Leetown, West Virginia 25430, USA. caird.rexroadiii@ars.usda.gov
Roger L Vallejo

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of molecular genetic technologies for broodstock management and selective breeding of aquaculture species is becoming increasingly more common with the continued development of genome tools and reagents. Several laboratories have produced genetic maps for rainbow trout to aid in the identification of loci affecting phenotypes of interest. These maps have resulted in the identification of many quantitative/qualitative trait loci affecting phenotypic variation in traits associated with albinism, disease resistance, temperature tolerance, sex determination, embryonic development rate, spawning date, condition factor and growth. Unfortunately, the elucidation of the precise allelic variation and/or genes underlying phenotypic diversity has yet to be achieved in this species having low marker densities and lacking a whole genome reference sequence. Experimental designs which integrate segregation analyses with linkage disequilibrium (LD) approaches facilitate the discovery of genes affecting important traits. To date the extent of LD has been characterized for humans and several agriculturally important livestock species but not for rainbow trout.

resultsWe observed that the level of LD between syntenic loci decayed rapidly at distances greater than 2 cM which is similar to observations of LD in other agriculturally important species including cattle, sheep, pigs and chickens. However, in some cases significant LD was also observed up to 50 cM. Our estimate of effective population size based on genome wide estimates of LD for the NCCCWA broodstock population was 145, indicating that this population will respond well to high selection intensity. However, the range of effective population size based on individual chromosomes was 75.51 - 203.35, possibly indicating that suites of genes on each chromosome are disproportionately under selection pressures.

conclusionsOur results indicate that large numbers of markers, more than are currently available for this species, will be required to enable the use of genome-wide integrated mapping approaches aimed at identifying genes of interest in rainbow trout.

Indexed as

Linkage DisequilibriumAnimalsChromosomesFemaleGenetic MarkersMaleMicrosatellite RepeatsOncorhynchus mykissPopulation DensityGenetic Markers

Identifiers

PMID20003428
PMCPMC2800115

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.