ArticleBMC medical genetics2009
Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population.
Article in BMC medical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- ADAM33 polymorphisms and susceptibility to allergic rhinitis: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Pooled it
- Association of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms with the risk of COPD: an updated meta-analysis of 2,644 cases and 4,804 controls.Molecular biology reports · 2015Pooled it
- Lack of association between the G+2044A polymorphism of interleukin-13 gene and chronic obstructive pulmonary disease: a meta-analysis.Molecular biology reports · 2014Pooled it
- The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD.Scientific reports · 2021Article
- A network-based approach to uncover microRNA-mediated disease comorbidities and potential pathobiological implications.NPJ systems biology and applications · 2019Article
- Article
- Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA.Molecular therapy. Nucleic acids · 2017Article
- Genetic polymorphism and chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2017Review
- Article
- A predictive model for the development of chronic obstructive pulmonary disease.Biomedical reports · 2015Article
- Associations of ABHD2 genetic variations with risks for chronic obstructive pulmonary disease in a Chinese Han population.PloS one · 2015Article
- Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD.BMC pulmonary medicine · 2014Article
- Gene polymorphisms and chronic obstructive pulmonary disease.Journal of cellular and molecular medicine · 2014Article
- Inflammatory bowel disease: An archetype disorder of outer environment sensor systems.World journal of gastrointestinal pharmacology and therapeutics · 2013Article
- Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study.BMC medical genomics · 2012Article
- Updates on the COPD gene list.International journal of chronic obstructive pulmonary disease · 2012Review
- Association of ADAM33 gene with susceptibility to COPD in Tibetan population of China.Molecular biology reports · 2011Article
- A disintegrin and metalloprotease 33 polymorphism association with COPD in long-term tobacco smokers of the ethnic Kashmiri population of India.Lung India : official organ of Indian Chest SocietyArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic obstructive pulmonary disease (COPD) is influenced by both environmental and genetic factors. ADAM33 (a disintegrin and metalloproteinase 33) has been one of the most exciting candidate genes for asthma since its first association with the disease in Caucasian populations. Recently, ADAM33 was shown to be associated with excessive decline of lung function and COPD. The aim of this study was to evaluate the potential relationship between polymorphisms of ADAM33 and COPD in a Han population in northeastern China.
methodsA total of 312 COPD patients and a control group of 319 healthy volunteers were recruited for this study. Eight polymorphic loci (V4, T+1, T2, T1, S2, S1, Q-1, and F+1) of ADAM33 were selected for genotyping. Genotypes were determined by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
resultsStatistically significant differences in the distributions of the T2G, T1G, S2C, and Q-1G alleles between patients and controls were observed (P < 0.001, odds ratio (OR) = 2.81, 95% confidence interval (CI) = 2.19-3.61; P < 0.001, OR = 2.60, 95% CI = 2.06-3.30; P = 0.03, OR = 1.31, 95% CI = 1.02-1.69; and P < 0.001, OR = 1.93, 95% CI = 1.50-2.50, respectively). Haplotype analysis showed that the frequencies of the CGGGGAGC, CGGGGAGT, CGGGCAGC, and CGGGGGGC haplotypes were significantly higher in the case group than in the control group (P = 0.0002, 0.0001, 0.0005, and 0.0074, respectively). In contrast, the haplotype CGAAGAGC was more common in the control group than in the case group (P < 0.0001).
conclusionThese preliminary results suggest an association between ADAM33 polymorphisms and COPD in a Chinese Han population.
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