ArticleBMC infectious diseases2009
Cryptic Leishmania infantum infection in Italian HIV infected patients.
Article in BMC infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The Global Prevalence of and Factors Associated with Parasitic Coinfection in People Living with Viruses: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2025Pooled it
- Prevalence of visceral leishmaniasis among people with HIV: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Pooled it
- T-cell activation and senescence in asymptomatic HIV/Leishmania infantum co-infection.PLoS neglected tropical diseases · 2025Article
- HIV and Mediterranean Zoonoses: A Review of the Literature.Infectious disease reports · 2022Review
- Third Case of Visceral Leishmaniasis in COVID-19: Mini Review Article.Pathogens (Basel, Switzerland) · 2022Review
- Identification of asymptomatic Leishmania infections: a scoping review.Parasites & vectors · 2022Article
- Article
- Genetic tools discriminate strains of Leishmania infantum isolated from humans and dogs in Sicily, Italy.PLoS neglected tropical diseases · 2020Article
- Role of asymptomatic and symptomatic humans as reservoirs of visceral leishmaniasis in a Mediterranean context.PLoS neglected tropical diseases · 2020Article
- Direct-acting antivirals and visceral leishmaniasis: a case report.BMC infectious diseases · 2019Article
- Subclinical Leishmania infection in patients with rheumatic diseases under biological drugs.Infection · 2018Article
- Asymptomatic carriers of Leishmania infantum in patients infected with human immunodeficiency virus (HIV) in Morocco.Parasitology research · 2018Article
- Prevalence and risk factors associated with Leishmania infection in Trang Province, southern Thailand.PLoS neglected tropical diseases · 2017Article
- Leishmaniasis-HIV coinfection: current challenges.HIV/AIDS (Auckland, N.Z.) · 2016Review
- Decentralized control of human visceral leishmaniasis in endemic urban areas of Brazil: a literature review.Tropical medicine and health · 2016Review
- Screening for subclinical Leishmania infection in HIV-infected patients living in eastern Spain.Pathogens and global health · 2014Article
- A case of imported Leishmania infantum cutaneous leishmaniasis; an unusual presentation occurring 19 years after travel.BMC infectious diseases · 2014Article
- Visceral leishmaniasis and HIV coinfection in the Mediterranean region.PLoS neglected tropical diseases · 2014Review
- Ultrasensitive real-time PCR for the clinical management of visceral leishmaniasis in HIV-Infected patients.The American journal of tropical medicine and hygiene · 2013Article
- Nitric oxide production by Peromyscus yucatanicus (Rodentia) infected with Leishmania (Leishmania) mexicana.Memorias do Instituto Oswaldo Cruz · 2013Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVisceral leishmaniasis (VL) is a protozoan diseases caused in Europe by Leishmania (L.) infantum. Asymptomatic Leishmania infection is more frequent than clinically apparent disease. Among HIV infected patients the risk of clinical VL is increased due to immunosuppression, which can reactivate a latent infection. The aims of our study were to assess the prevalence of asymptomatic L. infantum infection in HIV infected patients and to study a possible correlation between Leishmania parasitemia and HIV infection markers.
methodsOne hundred and forty-five HIV infected patients were screened for the presence of anti-Leishmania antibodies and L. infantum DNA in peripheral blood. Statistical analysis was carried out by using a univariate regression analysis.
resultsAntibodies to L. infantum were detected in 1.4% of patients. L. infantum DNA was detected in 16.5% of patients. Significant association for PCR-Leishmania levels with plasma viral load was documented (p = 0.0001).
conclusionIn our area a considerable proportion of HIV infected patients are asymptomatic carriers of L. infantum infection. A relationship between high HIV viral load and high parasitemic burden, possibly related to a higher risk of developing symptomatic disease, is suggested. PCR could be used for periodic screening of HIV patients to individuate those with higher risk of reactivation of L. infantum infection.
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