ArticleMolecular ecology2010
Heterothallism in Saccharomyces cerevisiae isolates from nature: effect of HO locus on the mode of reproduction.
Article in Molecular ecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Review
- Sporulation generates stress-dependent phenotypic variability in the heterothallic industrial Saccharomyces cerevisiae Ethanol Red.Scientific reports · 2026Article
- Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Domestication drives repeated evolution of sexual-asexual life cycle trade-offs in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Isolation and characterization of haploid heterothallic beer yeasts.Applied microbiology and biotechnology · 2025Article
- Wild yeast isolation by middle-school students reveals features of populations residing on North American oaks.G3 (Bethesda, Md.) · 2025Article
- Wild yeast isolation by middle school students reveals features of North American oak populations ofbioRxiv : the preprint server for biology · 2024Article
- Current Ethanol Production Requirements for the YeastInternational journal of microbiology · 2022Review
- Lessons from the Nakaseomyces: mating-type switching, DSB repair and evolution of Ho.Current genetics · 2021Review
- Hybridization ofMicroorganisms · 2021Article
- Repeated evolution of self-compatibility for reproductive assurance.Nature communications · 2018Article
- An Overview of the Function and Maintenance of Sexual Reproduction in Dikaryotic Fungi.Frontiers in microbiology · 2018Review
- New Lager Brewery Strains Obtained by Crossing Techniques UsingApplied and environmental microbiology · 2017Article
- Yeast for virus research.Microbial cell (Graz, Austria) · 2017Review
- An Evolutionary Perspective on Yeast Mating-Type Switching.Genetics · 2017Review
- Allelic variation, aneuploidy, and nongenetic mechanisms suppress a monogenic trait in yeast.Genetics · 2015Article
- Mating-type switching by chromosomal inversion in methylotrophic yeasts suggests an origin for the three-locus Saccharomyces cerevisiae system.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Improving industrial yeast strains: exploiting natural and artificial diversity.FEMS microbiology reviews · 2014Review
- Sex-determination system in the diploid yeast Zygosaccharomyces sapae.G3 (Bethesda, Md.) · 2014Article
- Dynamic large-scale chromosomal rearrangements fuel rapid adaptation in yeast populations.PLoS genetics · 2013Article
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9 authors.
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Abstract
Understanding the evolution of sex and recombination, key factors in the evolution of life, is a major challenge in biology. Studies of reproduction strategies of natural populations are important to complement the theoretical and experimental models. Fungi with both sexual and asexual life cycles are an interesting system for understanding the evolution of sex. In a study of natural populations of yeast Saccharomyces cerevisiae, we found that the isolates are heterothallic, meaning their mating type is stable, while the general belief is that natural S. cerevisiae strains are homothallic (can undergo mating-type switching). Mating-type switching is a gene-conversion process initiated by a site-specific endonuclease HO; this process can be followed by mother-daughter mating. Heterothallic yeast can mate with unrelated haploids (amphimixis), or undergo mating between spores from the same tetrad (intratetrad mating, or automixis), but cannot undergo mother-daughter mating as homothallic yeasts can. Sequence analysis of HO gene in a panel of natural S. cerevisiae isolates revealed multiple mutations. Good correspondence was found in the comparison of population structure characterized using 19 microsatellite markers spread over eight chromosomes and the HO sequence. Experiments that tested whether the mating-type switching pathway upstream and downstream of HO is functional, together with the detected HO mutations, strongly suggest that loss of function of HO is the cause of heterothallism. Furthermore, our results support the hypothesis that clonal reproduction and intratetrad mating may predominate in natural yeast populations, while mother-daughter mating might not be as significant as was considered.
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