ArticleGenes, brain, and behavior2010
COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traits.
Article in Genes, brain, and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between Catechol-O-Methyltransferase Val158Met (158G/A) Polymorphism and Suicide Susceptibility: A Meta-analysis.Journal of research in health sciences · 2017Pooled it
- Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression.Molecular psychiatry · 2014Pooled it
- No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data.BMC psychiatry · 2011Pooled it
- The Val158Met Polymorphism in 8-Year-Old Boys and Girls Moderates the Influence of Parenting Styles on Proactive Aggression: Testing the Sensitivity to the Environment.Brain sciences · 2023Article
- The role of psychiatric symptoms and environmental vulnerability factors in explaining the relationship between child maltreatment and suicidality: A prospective investigation.Journal of affective disorders · 2020Article
- Interaction between catechol-O-methyltransferase polymorphism and childhood trauma in suicidal ideation of patients with post-traumatic stress disorder.Brain and behavior · 2020Article
- The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.Scientific reports · 2018Article
- The role ofNeuropsychiatric disease and treatment · 2018Article
- Interacting Effect of Catechol-Frontiers in psychology · 2018Article
- Gene-Gene-Environment Interactions of Serotonin Transporter, Monoamine Oxidase A and Childhood Maltreatment Predict Aggressive Behavior in Chinese Adolescents.Frontiers in behavioral neuroscience · 2017Article
- Genetics of Aggression in Alzheimer's Disease (AD).Frontiers in aging neuroscience · 2017Article
- Older age may offset genetic influence on affect: The COMT polymorphism and affective well-being across the life span.Psychology and aging · 2016Article
- Disorganization, COMT, and Children's Social Behavior: The Norwegian Hypothesis of Legacy of Disorganized Attachment.Frontiers in psychology · 2016Article
- RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- Child maltreatment, impulsivity, and antisocial behavior in African American children: Moderation effects from a cumulative dopaminergic gene index.Development and psychopathology · 2015Article
- Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders.PloS one · 2015Article
- Early childhood sexual abuse increases suicidal intent.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2013Article
- Gene-environment studies and borderline personality disorder: a review.Current psychiatry reports · 2013Review
- Article
- Potential programming of dopaminergic circuits by early life stress.Psychopharmacology · 2011Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anger-related traits are regulated by genes as well as early environmental factors. Both childhood maltreatment and genes underlie vulnerability to suicidal behaviors, possibly by affecting the constitution of intermediate phenotypes such as anger traits. The aim of this study was to test the interaction between nine candidate genes and childhood maltreatment in modulating anger-related traits in 875 adult suicide attempters. The State-Trait Anger Expression Inventory and the Childhood Trauma Questionnaire were used to examine anger traits and traumatic childhood experiences, respectively. The functional polymorphism of the catecholamine-O-methyl-transferase (COMT) gene Val158Met significantly modulated the association between sexual abuse and anger-trait level (P = 0.001). In the presence of sexual abuse, individuals carrying the Val high-activity allele displayed greater disposition toward anger than individuals homozygous for the Met allele (P = 0.0003). Notably, none of the serotonin-related genes influenced the effect of childhood abuse on anger traits. The results of the present study suggest that anger-trait level is influenced by the interaction between childhood abuse and functional polymorphism in the COMT gene. This study was carried out in a population with a high frequency of childhood abuse and a high disposition toward anger, and replication in healthy subjects is needed.
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