ArticleEpilepsia2010
Spatiotemporal patterns of electrocorticographic very fast oscillations (> 80 Hz) consistent with a network model based on electrical coupling between principal neurons.
Article in Epilepsia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Network effects of traumatic brain injury: from infra slow to high frequency oscillations and seizures.Journal of computational neuroscience · 2025Article
- Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus.International journal of molecular sciences · 2022Article
- Alkaline brain pH shift in rodent lithium-pilocarpine model of epilepsy with chronic seizures.Brain research · 2021Article
- Data-driven method to infer the seizure propagation patterns in an epileptic brain from intracranial electroencephalography.PLoS computational biology · 2021Article
- A computational investigation of electrotonic coupling between pyramidal cells in the cortex.Journal of computational neuroscience · 2020Article
- A Role for Electrotonic Coupling Between Cortical Pyramidal Cells.Frontiers in computational neuroscience · 2019Article
- Targeting high frequency oscillations in epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
- Electrical synapses in mammalian CNS: Past eras, present focus and future directions.Biochimica et biophysica acta. Biomembranes · 2018Review
- Gap Junction Modulation of Low-Frequency Oscillations in the Cerebellar Granule Cell Layer.Cerebellum (London, England) · 2017Article
- Article
- Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning.Hippocampus · 2015Review
- Slow Spatial Recruitment of Neocortex during Secondarily Generalized Seizures and Its Relation to Surgical Outcome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Modeling the Generation of Phase-Amplitude Coupling in Cortical Circuits: From Detailed Networks to Neural Mass Models.BioMed research international · 2015Review
- Gap junction networks can generate both ripple-like and fast ripple-like oscillations.The European journal of neuroscience · 2014Article
- Spreading dynamics on spatially constrained complex brain networks.Journal of the Royal Society, Interface · 2013Article
- Mechanisms of physiological and epileptic HFO generation.Progress in neurobiology · 2012Review
- Axonal properties determine somatic firing in a model of in vitro CA1 hippocampal sharp wave/ripples and persistent gamma oscillations.The European journal of neuroscience · 2012Article
- Seizure localization using broadband EEG: comparison of conventional frequency activity, high-frequency oscillations, and infraslow activity.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2012Article
- Article
- Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells.The European journal of neuroscience · 2012Article
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7 authors.
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Abstract
purposeWe sought to characterize spatial and temporal patterns of electrocorticography (ECoG) very fast oscillations (> ∼80 Hz, VFOs) prior to seizures in human frontotemporal neocortex, and to develop a testable network model of these patterns.
methodsECoG data were recorded with subdural grids from two preoperative patients with seizures of frontal lobe onset in an epilepsy monitoring unit. VFOs were recorded from rat neocortical slices. A "cellular automaton" model of network oscillations was developed, extending ideas of Traub et al. (Neuroscience, 92, 1999, 407) and Lewis & Rinzel (Network: Comput Neural Syst, 11, 2000, 299); this model is based on postulated electrical coupling between pyramidal cell axons.
resultsLayer 5 of rat neocortex, in vitro, can generate VFOs when chemical synapses are blocked. Human epileptic neocortex, in situ, produces preseizure VFOs characterized by the sudden appearance of "blobs" of activity that evolve into spreading wavefronts. When wavefronts meet, they coalesce and propagate perpendicularly but never pass through each other. This type of pattern has been described by Lewis & Rinzel in cellular automaton models with spatially localized connectivity, and is demonstrated here with 120,000- to 5,760,000-cell models. We provide a formula for estimating VFO period from structural parameters and estimate the spatial scale of the connectivity. DISCUSSION: These data provide further evidence, albeit indirect, that preseizure VFOs are generated by networks of pyramidal neurons coupled by gap junctions, each predominantly confined to pairs of neurons having somata separated by < ∼1-2 mm. Plausible antiepileptic targets are tissue mechanisms, such as pH regulation, that influence gap-junction conductance.
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