ArticleBritish journal of pharmacology2010
Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats.
Article in British journal of pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 92 citations in OpenAlex.
- A Comprehensive Review of Metabolic Dysfunction-Associated Steatotic Liver Disease: Its Mechanistic Development Focusing on Methylglyoxal and Counterbalancing Treatment Strategies.International journal of molecular sciences · 2025Review
- Review
- Methylglyoxal in Cardiometabolic Disorders: Routes Leading to Pathology Counterbalanced by Treatment Strategies.Molecules (Basel, Switzerland) · 2023Review
- Vescalagin from Pink Wax Apple (Plants (Basel, Switzerland) · 2021Article
- Antiglycation Activity of Aucubin In Vitro and in Exogenous Methylglyoxal Injected Rats.Molecules (Basel, Switzerland) · 2019Article
- Ethyl Pyruvate Prevents Renal Damage Induced by Methylglyoxal-Derived Advanced Glycation End Products.Journal of diabetes research · 2019Article
- Methylglyoxal and insulin resistance in berberine-treated type 2 diabetic patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Article
- Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.International journal of molecular sciences · 2017Review
- Accumulation of intestinal tissue 3-deoxyglucosone attenuated GLP-1 secretion and its insulinotropic effect in rats.Diabetology & metabolic syndrome · 2016Article
- The strong relation between post-hemodialysis blood methylglyoxal levels and post-hemodialysis blood glucose concentration rise.Clinical and experimental nephrology · 2015Article
- Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo.Nutrients · 2015Article
- Antioxidation and antiglycation of Fagopyrum tataricum ethanol extract.Journal of food science and technology · 2015Article
- Targeting AGEs Signaling Ameliorates Central Nervous System Diabetic Complications in Rats.Advances in pharmacological sciences · 2015Article
- Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal.Cardiovascular diabetology · 2014Article
- Article
- Dietary fructose feeding increases adipose methylglyoxal accumulation in rats in association with low expression and activity of glyoxalase-2.Nutrients · 2013Article
- Methylglyoxal, obesity, and diabetes.Endocrine · 2013Review
- The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats.Cardiovascular diabetology · 2013Article
- Up-regulation of aldolase A and methylglyoxal production in adipocytes.British journal of pharmacology · 2013Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeAlagebrium is a breaker of cross-links in advanced glycation endproducts. However, the acute effects of alagebrium on methylglyoxal (MG), a major precursor of advanced glycation endproducts have not been reported. MG is a highly reactive endogenous metabolite, and its levels are elevated in diabetic patients. We investigated whether alagebrium attenuated the acute effects of exogenous MG on plasma MG levels, glucose tolerance and distribution of administered MG in different organs in Sprague-Dawley rats. EXPERIMENTAL APPROACH: We measured MG levels (by HPLC), glucose tolerance, adipose tissue glucose uptake, GLUT4, insulin receptor and insulin receptor substrate 1 (IRS-1) protein expression, and phosporylated IRS-1 in rats treated with MG at doses of either 17.25 mg*kg(-1) i.p. (MG-17 i.p.) or 50 mg*kg(-1) i.v. (MG-50 i.v.) with or without alagebrium, 100 mg*kg(-1) i.p. KEY
resultsAlagebrium attenuated the increased MG levels in the plasma, aorta, heart, kidney, liver, lung and urine after MG administration. In MG-treated rats, glucose tolerance was impaired, plasma insulin levels were higher and insulin-stimulated glucose uptake by adipose tissue was reduced, relative to the corresponding control groups. In rats treated with MG-50 i.v., GLUT4 protein expression and IRS-1 tyrosine phosphorylation were decreased. Alagebrium pretreatment attenuated these effects of MG. In an in vitro assay, alagebrium reduced the amount of detectable MG. CONCLUSIONS AND IMPLICATIONS: Alagebrium acutely attenuated MG-induced glucose intolerance, suggesting a possible preventive role for alagebrium against the harmful effects of MG.
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