ArticleBritish journal of pharmacology2010
Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon.
Article in British journal of pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Otilonium Bromide Prevents Cholinergic Changes in the Distal Colon Induced by Chronic Water Avoidance Stress, a Rat Model of Irritable Bowel Syndrome.International journal of molecular sciences · 2023Article
- Recommendations for evaluation of bladder and bowel function in pre-clinical spinal cord injury research.The journal of spinal cord medicine · 2020Review
- Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk.Journal of clinical medicine · 2019Review
- Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract.Current molecular pharmacology · 2018Review
- Endogenous CRF in rat large intestine mediates motor and secretory responses to stress.Neurogastroenterology and motility · 2016Article
- Corticotropin-releasing factor receptor type 1 and type 2 interaction in irritable bowel syndrome.Journal of gastroenterology · 2015Review
- Role of Corticotropin-releasing Factor Signaling in Stress-related Alterations of Colonic Motility and Hyperalgesia.Journal of neurogastroenterology and motility · 2015Article
- Role of Corticotropin-releasing Factor in Gastrointestinal Permeability.Journal of neurogastroenterology and motility · 2015Article
- Dietary glutamate: interactions with the enteric nervous system.Journal of neurogastroenterology and motility · 2014Article
- Mast cell expression of the serotonin1A receptor in guinea pig and human intestine.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Corticotropin-releasing factor receptor subtype 2 in human colonic mucosa: down-regulation in ulcerative colitis.World journal of gastroenterology · 2013Article
- Article
- Stress and the Stomach: Corticotropin-Releasing Factor May Protect the Gastric Mucosa in Stress Through Involvement of Glucocorticoids.Cellular and molecular neurobiology · 2012Article
- Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents.Gastroenterology · 2011Article
- Urocortin 1 modulates immunosignaling in a rat model of colitis via corticotropin-releasing factor receptor 2.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Effects of peripherally administered urocortin 3 on feeding behavior and gastric emptying in mice.Experimental and therapeutic medicine · 2011Article
- Corticotrophin-releasing factor, related peptides, and receptors in the normal and inflamed gastrointestinal tract.Frontiers in neuroscience · 2011Article
- Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2009Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
background and purposeUrocortins (Ucns) 1, 2 and 3 are corticotropin-releasing factor (CRF)-related neuropeptides and may be involved in neural regulation of colonic motor functions. Nevertheless, details of the neural mechanism of action for Ucns have been unclear. We have, here, tested the hypothesis that Ucns act in the enteric nervous system (ENS) to influence colonic motor behaviour. EXPERIMENTAL APPROACH: We used intracellular recording with 'sharp' microelectrodes, followed by intraneuronal injection of biocytin, and immunohistochemical localization of CRF(1) and CRF(2) receptors in guinea pig colonic tissue. KEY
resultsApplication of Ucn1 depolarized membrane potentials and elevated excitability in 58% of AH-type and 60% of S-type colonic myenteric neurons. In most of the neurons tested, depolarizing responses evoked by Ucn-1 were suppressed by the CRF(1) receptor antagonist NBI 27914, but were unaffected by the CRF(2) receptor antagonist antisauvagine-30. The selective CRF(2) receptor agonists, Ucn2 and Ucn3, evoked depolarizing responses in 12 and 8% of the AH-type myenteric neurons, respectively, and had no effect on S-type neurons. Antisauvagine-30, but not NBI 27914, suppressed these Ucn2- and Ucn3-evoked responses. Immunohistochemical staining identified CRF(1) as the predominant CRF receptor subtype expressed by ganglion cell somas, while CRF(2)-immunoreactive neuronal somas were sparse. Ucns did not affect excitatory synaptic transmission in the ENS. CONCLUSIONS AND IMPLICATIONS: The results suggest that Ucns act as neuromodulators to influence myenteric neuronal excitability. The excitatory action of Ucn1 in myenteric neurons was primarily at CRF(1) receptors, and the excitatory action of Ucn2 and Ucn3 was at CRF(2) receptors.
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