ReviewBritish journal of clinical pharmacology2009
Recent progress in the genetics of common obesity.
Review in British journal of clinical pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status.Critical reviews in food science and nutrition · 2024Pooled it
- Understanding eating in the absence of hunger among young children: a systematic review of existing studies.Appetite · 2015Pooled it
- Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study.BMC medical genetics · 2013Pooled it
- Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Specific Functions of Melanocortin 3 Receptor (MC3R)Journal of clinical research in pediatric endocrinology · 2023Review
- The miR-668 binding site variant rs1046322 onFrontiers in endocrinology · 2023Article
- Review
- Article
- Identifying actionable lifestyle risk factors for obesity research and intervention: Challenges and opportunities for Pacific Island health researchers.The Lancet regional health. Western Pacific · 2020Article
- Integrative Analysis Revealing Human Adipose-Specific Genes and Consolidating Obesity Loci.Scientific reports · 2019Article
- AreBMJ open · 2017Article
- An autonomous metabolic role for Spen.PLoS genetics · 2017Article
- Changes in Obesity Odds Ratio among Iranian Adults, since 2000: Quadratic Inference Functions Method.Computational and mathematical methods in medicine · 2016Article
- Diet, behavior and immunity across the lifespan.Neuroscience and biobehavioral reviews · 2015Review
- The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients.Obesity surgery · 2015Article
- Effects of Maternal Obesity on Fetal Programming: Molecular Approaches.Cold Spring Harbor perspectives in medicine · 2015Review
- Genomic medicine in gastroenterology: A new approach or a new specialty?World journal of gastroenterology · 2015Review
- Obesity and Related Factors in Iran: The STEPS Survey, 2011.Iranian Red Crescent medical journal · 2015Article
- Article
- What the Genetic Background of Individuals with Asthma and Obesity Can Reveal: Is β2-Adrenergic Receptor Gene Polymorphism Important?Pediatric allergy, immunology, and pulmonology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The genetic contribution to interindividual variation in common obesity has been estimated at 40-70%. Yet, despite a relatively high heritability, the search for obesity susceptibility genes has been an arduous task. This paper reviews recent progress made in the obesity genetics field with an emphasis on established obesity susceptibility loci identified through candidate gene as well as genome-wide studies. For the last 15 years, candidate gene and genome-wide linkage studies have been the two main genetic epidemiological approaches to identify genetic loci for common traits, yet progress has been slow and success limited. Only recently have candidate gene studies started to succeed; by means of large-scale studies and meta-analyses at least five variants in four candidate genes have been found to be robustly associated with obesity-related traits. Genome-wide linkage studies, however, have so far not been able to pinpoint genetic loci for common obesity. The genome-wide association approach, which has become available in recent years, has dramatically changed the pace of gene discoveries for common disease, including obesity. Three waves of large-scale high-density genome-wide association studies have already discovered at least 15 previously unanticipated genetic loci incontrovertibly associated with body mass index and extreme obesity risk. Although the combined contribution of these loci to the variation in obesity risk at the population level is small and their predictive value is typically low, these recently discovered loci are set to improve fundamentally our insights into the pathophysiology of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.