ArticleThe Journal of infectious diseases2010
The interleukin 6 -174 C/C genotype predicts greater rhinovirus illness.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
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- Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol.Psychoneuroendocrinology · 2025Article
- Repositioned Natural Compounds and Nanoformulations: A Promising Combination to Counteract Cell Damage and Inflammation in Respiratory Viral Infections.Molecules (Basel, Switzerland) · 2023Review
- Analysis of Gene Single Nucleotide Polymorphisms in COVID-19 Disease Highlighting the Susceptibility and the Severity towards the Infection.Diagnostics (Basel, Switzerland) · 2022Article
- Risky Early Family Environment and Genetic Associations with Adult Metabolic Dysregulation.International journal of environmental research and public health · 2022Article
- Exploring the Links between Personality and Immune Function.Personality and individual differences · 2022Article
- Hallmarks of Severe COVID-19 Pathogenesis:Frontiers in immunology · 2022Review
- Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection.Archives of virology · 2021Review
- SARS-CoV-2 Antigenemia as a Confounding Factor in Immunodiagnostic Assays: A Case Study.Viruses · 2021Article
- Genetic influences on viral-induced cytokine responses in the lung.Mucosal immunology · 2021Review
- Genetics Insight for COVID-19 Susceptibility and Severity: A Review.Frontiers in immunology · 2021Review
- INTERACTIONS AMONG INTERLEUKIN-6, C-REACTIVE PROTEIN AND INTERLEUKIN-6 (-174) G/C POLYMORPHISM IN THE PATHOGENESIS OF CROHN'S DISEASE AND ULCERATIVE COLITIS.Acta clinica Croatica · 2020Article
- Year-Long Rhinovirus Infection is Influenced by Atmospheric Conditions, Outdoor Air Virus Presence, and Immune System-Related Genetic Polymorphisms.Food and environmental virology · 2019Article
- Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies.Frontiers in pharmacology · 2018Review
- Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.PLoS pathogens · 2017Article
- Early-life Socio-economic Status and Adult Health: The Role of Positive Affect.Stress and health : journal of the International Society for the Investigation of Stress · 2017Article
- Gene expression patterns induced at different stages of rhinovirus infection in human alveolar epithelial cells.PloS one · 2017Article
- Contribution of IL6 -174 G>C and IL1B +3954 C>T polymorphisms to congenital infection with Toxoplasma gondii.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Immunobiotic Lactobacillus administered post-exposure averts the lethal sequelae of respiratory virus infection.Antiviral research · 2015Article
- Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.Pulmonary pharmacology & therapeutics · 2015Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIn adults and children with respiratory syncytial virus (RSV) infection, a polymorphism in the interleukin 6 (IL-6) promoter at position -174 predicts illness magnitude. In addition, polymorphisms in the interleukin 10 (IL-10), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) genes are associated with immune responsiveness and the frequency of complications. Here, the effect of these polymorphisms on illness and seroconversion during infection with rhinovirus type 39 (RV39) was evaluated.
methodsSeventy-two adults were genotyped for the selected polymorphisms, experimentally exposed to RV39, and followed to track infection, seroconversion, and symptoms and signs of illness. Regression analysis was used to determine whether these polymorphisms predicted seroconversion and illness magnitude in 57 infected subjects.
resultsThe low-production IL-6 -174 phenotype (C/C genotype) was associated with greater symptom magnitudes, and the IFN-gamma phenotype +874 predicted the frequency of seroconversion. No relationship between the IL-10 or TNF-alpha polymorphisms and any measured outcome was documented. The concentration of IL-6 protein, as measured in nasal wash fluids from subjects, was positively correlated with symptom magnitude, but it was independent of the IL-6 -174 genotypes representing the high- and low-production phenotypes.
conclusionsThese results document statistically significant associations between the IL-6 -174 and IFN-gamma +874 polymorphisms and specific responses to experimental RV39 infection. For the IL-6 -174 polymorphism, the results replicate those for experimental RSV infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.