ArticleJournal of neurotrauma2010
Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology.
Article in Journal of neurotrauma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- Effect of acupuncture therapy for postponing Wallerian degeneration of cerebral infarction as shown by diffusion tensor imaging.Journal of alternative and complementary medicine (New York, N.Y.) · 2012Trial
- Metabolic and Structural Alterations in the Motor System Following Spinal Cord Injury: An In-VivoJournal of neuroscience research · 2025Article
- The 419th Aspartic Acid of Neural Membrane Protein Enolase 2 Is a Key Residue Involved in the Axonal Growth of Motor Neurons Mediated by Interaction between Enolase 2 Receptor and Extracellular Pgk1 Ligand.International journal of molecular sciences · 2024Article
- Improved Recovery of Complete Spinal Cord Transection by a Plasma-Modified Fibrillar Scaffold.Polymers · 2024Article
- Premarin Reduces Neurodegeneration and Promotes Improvement of Function in an Animal Model of Spinal Cord Injury.International journal of molecular sciences · 2022Article
- Article
- The spatiotemporal spread of cervical spinal cord contusion injury pathology revealed by 3D in-line phase contrast synchrotron X-ray microtomography.Experimental neurology · 2021Article
- Shock waves promote spinal cord repair via TLR3.JCI insight · 2020Article
- Assessment of neuron-specific enolase, S100B and malondialdehyde levels in serum and vitreous of patients with proliferative diabetic retinopathy.International ophthalmology · 2020Article
- New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection.Brain sciences · 2018Review
- Subject-specific regional measures of water diffusion are associated with impairment in chronic spinal cord injury.Neuroradiology · 2017Article
- Differential Neuroproteomic and Systems Biology Analysis of Spinal Cord Injury.Molecular & cellular proteomics : MCP · 2016Article
- A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis.Journal of neuroinflammation · 2015Article
- Imaging techniques in spinal cord injury.World neurosurgery · 2014Review
- Article
- Metabolite profiles correlate closely with neurobehavioral function in experimental spinal cord injury in rats.PloS one · 2012Article
- Syndromics: a bioinformatics approach for neurotrauma research.Translational stroke research · 2011Article
- Vascular Pathology as a Potential Therapeutic Target in SCI.Translational stroke research · 2011Article
- 1H-MRS in spinal cord injury: acute and chronic metabolite alterations in rat brain and lumbar spinal cord.The European journal of neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Longitudinal in vivo proton magnetic resonance spectroscopy (1H-MRS) and immunohistochemistry were performed to investigate the tissue degeneration in traumatically injured rat spinal cord rostral and caudal to the lesion epicenter. On 1H-MRS significant decreases in N-acetyl aspartate (NAA) and total creatine (Cr) levels in the rostral, epicenter, and caudal segments were observed by 14 days, and levels remained depressed up to 56 days post-injury (PI). In contrast, the total choline (Cho) levels increased significantly in all three segments by 14 days PI, but recovered in the epicenter and caudal, but not the rostral region, at 56 days PI. Immunohistochemistry demonstrated neuronal cell death in the gray matter, and reactive astrocytes and axonal degeneration in the dorsal, lateral, and ventral white-matter columns. These results suggest delayed tissue degeneration in regions both rostrally and caudally from the epicenter in the injured spinal cord tissue. A rostral-caudal asymmetry in tissue recovery was seen both on MRI-observed hyperintense lesion volume and the Cho, but not NAA and Cr, levels at 56 days PI. These studies suggest that dynamic metabolic changes take place in regions away from the epicenter in injured spinal cord.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.