ArticleFree radical research2010
Traditional reactive carbonyl scavengers do not prevent the carbonylation of brain proteins induced by acute glutathione depletion.
Article in Free radical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- A novel two-way rebalancing strategy for identifying carbonylation sites.BMC bioinformatics · 2023Article
- Oxidative stress impairs the meat quality of broiler by damaging mitochondrial function, affecting calcium metabolism and leading to ferroptosis.Animal bioscience · 2022Article
- Antiaging function of Chinese pond turtle (Frontiers in nutrition · 2022Article
- Reactive oxygen species-induced protein carbonylation promotes deterioration of physiological activity of wheat seeds.PloS one · 2022Article
- CarSite-II: an integrated classification algorithm for identifying carbonylated sites based on K-means similarity-based undersampling and synthetic minority oversampling techniques.BMC bioinformatics · 2021Article
- Glycinebetaine mitigated the photoinhibition of photosystem II at high temperature in transgenic tomato plants.Photosynthesis research · 2021Article
- Effect of Freeze-Thaw Cycles on the Oxidation of Protein and Fat and Its Relationship with the Formation of Heterocyclic Aromatic Amines and Advanced Glycation End Products in Raw Meat.Molecules (Basel, Switzerland) · 2021Article
- Effects of Cavitation Jet Treatment on the Structure and Emulsification Properties of Oxidized Soy Protein Isolate.Foods (Basel, Switzerland) · 2020Article
- Taurine administration ablates sepsis induced diaphragm weakness.Respiratory physiology & neurobiology · 2020Article
- Mechanism of Protein Carbonylation in Glutathione-Depleted Rat Brain Slices.Neurochemical research · 2018Article
- Involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase-mediated signaling transduction.The Journal of biological chemistry · 2013Article
- Protein carbonylation and aggregation precede neuronal apoptosis induced by partial glutathione depletion.ASN neuro · 2012Article
- Mass spectrometry of fatty aldehydes.Biochimica et biophysica acta · 2011Review
- Hydralazine modifies Aβ fibril formation and prevents modification by lipids in vitro.Biochemistry · 2010Article
- Direct reaction of taurine with malondialdehyde: evidence for taurine as a scavenger of reactive carbonyl species.Redox report : communications in free radical research · 2010Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
This study investigated the effect of reactive carbonyl species (RCS)-trapping agents on the formation of protein carbonyls during depletion of brain glutathione (GSH). To this end, rat brain slices were incubated with the GSH-depletor diethyl maleate in the absence or presence of chemically different RCS scavengers (hydralazine, methoxylamine, aminoguanidine, pyridoxamine, carnosine, taurine and z-histidine hydrazide). Despite their strong reactivity towards the most common RCS, none of the scavengers tested, with the exception of hydralazine, prevented protein carbonylation. These findings suggest that the majority of protein-associated carbonyl groups in this oxidative stress paradigm do not derive from stable lipid peroxidation products like malondialdehyde (MDA), acrolein and 4-hydroxynonenal (4-HNE). This conclusion was confirmed by the observation that the amount of MDA-, acrolein- and 4-HNE-protein adducts does not increase upon GSH depletion. Additional studies revealed that the efficacy of hydralazine at preventing carbonylation was due to its ability to reduce oxidative stress, most likely by inhibiting mitochondrial production of superoxide and/or by scavenging lipid free radicals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.