ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2009
Interindividual variation in functionally adapted trait sets is established during postnatal growth and predictable based on bone robustness.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Placental Size Is Associated Differentially With Postnatal Bone Size and Density.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Trial
- Impact of outer width of the metacarpal diaphysis on the identification of low bone mass in children.PloS one · 2025Article
- Sex and External Size Specific Limitations in Assessing Bone Health From Adult Hand Radiographs.JBMR plus · 2022Article
- Navigating the Pathway to Care in Adults With Cerebral Palsy.Frontiers in neurology · 2021Review
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- Differential Adaptive Response of Growing Bones From Two Female Inbred Mouse Strains to Voluntary Cage-Wheel Running.JBMR plus · 2018Article
- Tibia functionality and Division II female and male collegiate athletes from multiple sports.PeerJ · 2018Article
- Bone robusticity in two distinct skeletal dysplasias diverges from established patterns.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Femoral Neck External Size but not aBMD Predicts Structural and Mass Changes for Women Transitioning Through Menopause.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Canalization Leads to Similar Whole Bone Mechanical Function at Maturity in Two Inbred Strains of Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Astragalus Extract Mixture HT042 Improves Bone Growth, Mass, and Microarchitecture in Prepubertal Female Rats: A Microcomputed Tomographic Study.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Mapping the natural variation in whole bone stiffness and strength across skeletal sites.Bone · 2014Article
- Are we taking full advantage of the growing number of pharmacological treatment options for osteoporosis?Current opinion in pharmacology · 2014Review
- Characterization of complex, co-adapted skeletal biomechanics phenotypes: a needed paradigm shift in the genetics of bone structure and function.Current osteoporosis reports · 2014Article
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- Skeletal growth and the changing genetic landscape during childhood and adulthood.American journal of physical anthropology · 2013Article
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- Functional interactions among morphologic and tissue quality traits define bone quality.Clinical orthopaedics and related research · 2011Review
- Sex-specific regulation of body size and bone slenderness by the acid labile subunit.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Genetically determined phenotype covariation networks control bone strength.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Adults acquire unique sets of morphological and tissue-quality bone traits that are predictable based on robustness and deterministic of strength and fragility. How and when individual trait sets arise during growth has not been established. Longitudinal structural changes of the metacarpal diaphysis were measured for boys and girls from 3 mo to 8 yr of age using hand radiographs obtained from the Bolton-Brush collection. Robustness varied approximately 2-fold among boys and girls, and individual values were established by 2 yr of age, indicating that genetic and environmental factors controlling the relationship between growth in width and growth in length were established early during postnatal growth. Significant negative correlations between robustness and relative cortical area and a significant positive correlation between robustness and a novel measure capturing the efficiency of growth indicated that coordination of the subperiosteal and endocortical surfaces was responsible for this population acquiring a narrow range of trait sets that was predictable based on robustness. Boys and girls with robust diaphyses had proportionally thinner cortices to minimize mass, whereas children with slender diaphyses had proportionally thicker cortices to maximize stiffness. Girls had more slender metacarpals with proportionally thicker cortices compared with boys at all prepubertal ages. Although postnatal growth patterns varied in fundamentally different ways with sex and robustness, the dependence of trait sets on robustness indicated that children sustained variants affecting subperiosteal growth because they shared a common biological factor regulating functional adaptation. Considering the natural variation in acquired trait sets may help identify determinants of fracture risk, because age-related bone loss and gain will affect slender and robust structures differently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.