Evidence map›Paper›PMID 20001423›Full record

ReviewAutoimmunity2010

Immune pathology associated with altered actin cytoskeleton regulation.

Dilki C Wickramarachchi, Argyrios N Theofilopoulos, Dwight H Kono

Abstract readReview
In one paragraph

Review in Autoimmunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dilki C WickramarachchiDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Argyrios N Theofilopoulos
Dwight H Kono
Scripps Research Institute · US

Funding

T Cell Homeostasis in Systemic AutoimmunityR01AR031203 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI THEOFILOPOULOS, ARGYRIOS N · 1986 to 2012
$4.9M
Genetic Basis of Systemic AutoimmunityR37AR039555 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI THEOFILOPOULOS, ARGYRIOS N · 2003 to 2012
$4.2M
Defining the effector gene repertoire in systemic autoimmunity by ENU mutagenesisR01AR053731 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI KONO, DWIGHT H · 2007 to 2011
$2.5M
TYPE I INTERFERONS IN LUPUSR01AR053228 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI THEOFILOPOULOS, ARGYRIOS N · 2006 to 2010
$2.0M
T CELL ANTIGEN RECEPTOR GENES IN AUTOIMMUNITYR01AR039555 · NIAMS · SCRIPPS RESEARCH INSTITUTE · PI THEOFILOPOULOS, ARGYRIOS N · 1988 to 2002
$1.4M
CELL CYCLE AND APOPTOSIS GENES IN IMMUNOLOGIC SENESCENCER01AG015061 · NIA · SCRIPPS RESEARCH INSTITUTE · PI THEOFILOPOULOS, ARGYRIOS N · 1998 to 2002
$907k
NIAMS NIH HHS R01 AR031203NIAMS NIH HHS R01 AR039555NIAMS NIH HHS R01 AR053228NIAMS NIH HHS R01 AR053731NIAMS NIH HHS R37 AR039555NIA NIH HHS R01 AG015061
6 · The paper itself

Abstract

The actin cytoskeleton plays a crucial role in a variety of important cellular processes required for normal immune function, including locomotion, intercellular interactions, endocytosis, cytokinesis, signal transduction, and maintenance of cell morphology. Recent studies have uncovered not only many of the components and mechanisms that regulate the cortical actin cytoskeleton but have also revealed significant immunopathological consequences associated with genetic alteration of actin cytoskeletal regulatory genes. These advances have provided new insights into the role of cortical actin cytoskeletal regulation in a number of immune cell functions and have identified cytoskeletal regulatory proteins critical for normal immune system activity and susceptibility to autoimmunity.

Indexed as

ActinsAnimalsAutoimmune DiseasesCytoskeletonHumansActins

Identifiers

PMID20001423
PMCPMC3660107
OpenAlexW2091834324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.