Evidence map›Paper›PMID 20001254›Full record

ArticleTissue engineering. Part A2010

Principles of biomimetic vascular network design applied to a tissue-engineered liver scaffold.

David M Hoganson, Howard I Pryor, Ira D Spool, Owen H Burns, J Randall Gilmore, Joseph P Vacanti

Open access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Unconventional Biomaterials for Cardiovascular Tissue Engineering.Current opinion in biomedical engineering · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Physiologically relevant organs on chips.Biotechnology journal · 2014
    Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

David M HogansonDepartment of Surgery, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Howard I Pryor
Ira D Spool
Owen H Burns
J Randall Gilmore
Joseph P Vacanti
Massachusetts General Hospital · US

Funding

RESEARCH TRAINING IN ALIMENTARY TRACT SURGERYT32DK007754 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI HODIN, RICHARD A. · 1997 to 2025
$6.5M
Biliary morphogenesis and bile canaliculi integrationF32DK076349 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI HOGANSON, DAVID · 2006 to 2007
$99k
NIDDK NIH HHS F32 DK076349-01NIDDK NIH HHS T32 DK07754-09
6 · The paper itself

Abstract

Branched vascular networks are a central component of scaffold architecture for solid organ tissue engineering. In this work, seven biomimetic principles were established as the major guiding technical design considerations of a branched vascular network for a tissue-engineered scaffold. These biomimetic design principles were applied to a branched radial architecture to develop a liver-specific vascular network. Iterative design changes and computational fluid dynamic analysis were used to optimize the network before mold manufacturing. The vascular network mold was created using a new mold technique that achieves a 1:1 aspect ratio for all channels. In vitro blood flow testing confirmed the physiologic hemodynamics of the network as predicted by computational fluid dynamic analysis. These results indicate that this biomimetic liver vascular network design will provide a foundation for developing complex vascular networks for solid organ tissue engineering that achieve physiologic blood flow.

Indexed as

Biomimetic MaterialsBlood CirculationBlood VesselsLiverTissue EngineeringTissue Scaffolds

Identifiers

PMID20001254
PMCPMC2952124
OpenAlexW1998187761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.