ArticleJournal of the American Chemical Society2010
An antibiotic-resistance enzyme from a deep-sea bacterium.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Contributions of intra- and extracellular antibiotic degradation to collective [Formula: see text]-lactam survival.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Geographics and bacterial networks differently shape the acquired and latent global sewage resistomes.Nature communications · 2025Article
- Review of the Presence and Phage-Mediated Transfer of ARGs in Biofilms.Microorganisms · 2025Review
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- Article
- β-Lactams from the Ocean.Marine drugs · 2023Review
- Antibiotic resistance genes on the Qinghai-Tibet Plateau above an elevation of 5,000 m.Environmental science and pollution research international · 2022Article
- Mutation of the conserved Asp-Asp pair impairs the structure, function, and inhibition of CTX-M Class A β-lactamase.FEBS letters · 2021Article
- Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.Chemical reviews · 2021Review
- Inhibition of theACS infectious diseases · 2021Article
- Antibacterial and anticancer activities of orphan biosynthetic gene clusters from Atlantis II Red Sea brine pool.Microbial cell factories · 2019Article
- Bactericidal assessment of nano-silver on emerging and re-emerging human pathogens.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2019Article
- Comparative mangrove metagenome reveals global prevalence of heavy metals and antibiotic resistome across different ecosystems.Scientific reports · 2018Article
- The Prevalence of Antibiotic Resistant Diarrhogenic Bacterial Species in Surface Waters, South Eastern Nigeria.Ethiopian journal of health sciences · 2017Article
- Astrobiology as a framework for investigating antibiotic susceptibility: a study of Halomonas hydrothermalis.Journal of the Royal Society, Interface · 2017Article
- Novel thermostable antibiotic resistance enzymes from the Atlantis II Deep Red Sea brine pool.Microbial biotechnology · 2017Article
- Self-resistance in Streptomyces, with Special Reference to β-Lactam Antibiotics.Molecules (Basel, Switzerland) · 2016Review
- Class D β-lactamases do exist in Gram-positive bacteria.Nature chemical biology · 2016Article
- Characterization of a novel metallo-β-lactamases fold hydrolase from Pelagibacterium halotolerans, a marine halotolerant bacterium isolated from East China Sea.Extremophiles : life under extreme conditions · 2016Article
- Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography.Journal of the American Chemical Society · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We describe herein a highly proficient class A beta-lactamase OIH-1 from the bacterium Oceanobacillus iheyensis, whose habitat is the sediment at a depth of 1050 m in the Pacific Ocean. The OIH-1 structure was solved by molecular replacement and refined at 1.25 A resolution. OIH-1 has evolved to be an extremely halotolerant beta-lactamase capable of hydrolyzing its substrates in the presence of NaCl at saturating concentration. Not only is this the most highly halotolerant bacterial enzyme structure known to date, it is also the highest resolution halophilic protein structure yet determined. Evolution of OIH-1 in the salinity of the ocean has resulted in a molecular surface that is coated with acidic residues, a marked difference from beta-lactamases of terrestrial sources. OIH-1 is the first example of an antibiotic-resistance enzyme that has evolved in the depths of the ocean in isolation from clinical selection and gives us an extraordinary glimpse into protein evolution under extreme conditions. It represents evidence for the existence of a reservoir of antibiotic-resistance enzymes in nature among microbial populations from deep oceanic sources.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.