ArticleBiochemistry2010
Nucleotide excision repair of a DNA interstrand cross-link produces single- and double-strand breaks.
Article in Biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- RecA and RecB: probing complexes of DNA repair proteins with mitomycin C in liveJournal of the Royal Society, Interface · 2022Article
- Article
- Limited Capacity or Involvement of Excision Repair, Double-Strand Breaks, or Translesion Synthesis for Psoralen Cross-Link Repair inGenetics · 2018Article
- Photochemical Generation of Benzyl Cations That Selectively Cross-Link Guanine and Cytosine in DNA.Organic letters · 2016Article
- Nucleotide excision repair of chemically stabilized analogues of DNA interstrand cross-links produced from oxidized abasic sites.Biochemistry · 2014Article
- Investigation of bacterial nucleotide excision repair using single-molecule techniques.DNA repair · 2014Review
- Looking beneath the surface to determine what makes DNA damage deleterious.Current opinion in chemical biology · 2014Review
- Synthesis of cross-linked DNA containing oxidized abasic site analogues.The Journal of organic chemistry · 2014Article
- Photoswitchable formation of a DNA interstrand cross-link by a coumarin-modified nucleotide.Angewandte Chemie (International ed. in English) · 2014Article
- DNA interstrand cross-linking upon irradiation of aryl halide C-nucleotides.The Journal of organic chemistry · 2014Article
- Abasic and oxidized abasic site reactivity in DNA: enzyme inhibition, cross-linking, and nucleosome catalyzed reactions.Accounts of chemical research · 2014Article
- Insight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleases.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- DNA damage by reactive species: Mechanisms, mutation and repair.Journal of biosciences · 2012Review
- Direct formation of the C5'-radical in the sugar-phosphate backbone of DNA by high-energy radiation.The journal of physical chemistry. B · 2012Article
- Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids.Free radical research · 2012Review
- Repair of the major lesion resulting from C5'-oxidation of DNA.Biochemistry · 2011Article
- Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model.Nucleic acids research · 2010Article
- Mammalian nucleotide excision repair proteins and interstrand crosslink repair.Environmental and molecular mutagenesis · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The DNA radical resulting from formal abstraction of a hydrogen atom from the thymidine methyl group, 5-(2'-deoxyuridinyl)methyl radical, forms interstrand cross-links with the opposing 2'-deoxyadenosine. This is the first chemically characterized, radical-mediated cross-link between two opposing nucleotides. In addition, cross-linking between opposing bases in the duplex is less common than between those separated by one or two nucleotides. The first step in cross-link repair was investigated using the UvrABC bacterial nucleotide excision repair system. UvrABC incised both strands of the cross-linked DNA, although the strand containing the cross-linked purine was preferred by the enzyme in two different duplexes. The incision sites in one strand were spaced 11-14 nucleotides apart, as is typical for UvrABC incision. The majority of incisions occur at the third phosphate from the 3'-side of the cross-link and eighth or ninth phosphate on the 5'-side. In addition, cleavage was found to occur on both strands, producing double-strand breaks in approximately 25-29% of the incision events. This is the first example of double-strand cleavage during nucleotide excision repair of cross-linked DNA that does not already contain a strand break in the vicinity of the cross-link.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.