ArticleAnalytical chemistry2010
Quantitative, label-free detection of five protein biomarkers using multiplexed arrays of silicon photonic microring resonators.
Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed.
- Single-Particle Photothermal Microscopy Using On-Chip Silicon Nitride Microring Resonators.The journal of physical chemistry. A · 2026Article
- Shining the Path of Precision Diagnostic: Advancements in Photonic Sensors for Liquid Biopsy.Biosensors · 2025Review
- Selective modal excitation in a multimode nanoslit by interference of surface plasmon waves.Nanoscale advances · 2025Article
- High-Q WGM microcavity-based optofluidic sensor technologies for biological analysis.Biomicrofluidics · 2024Review
- Biofunctionalization of Multiplexed Silicon Photonic Biosensors.Biosensors · 2022Review
- An Optimization Framework for Silicon Photonic Evanescent-Field Biosensors Using Sub-Wavelength Gratings.Biosensors · 2022Article
- Dually nanocoated planar waveguides towards multi-parameter sensing.Scientific reports · 2021Article
- Microfluidic Packaging Integration with Electronic-Photonic Biosensors Using 3D Printed Transfer Molding.Biosensors · 2020Article
- Whispering-Gallery Sensors.Matter · 2020Review
- Advances in Optical Single-Molecule Detection: En Route to Supersensitive Bioaffinity Assays.Angewandte Chemie (International ed. in English) · 2020Review
- Multi-Parameter Sensing in a Multimode Self-Interference Micro-Ring Resonator by Machine Learning.Sensors (Basel, Switzerland) · 2020Article
- Recent advances in environmental and clinical analysis using microring resonator-based sensors.Current opinion in environmental science & health · 2019Article
- Janus electrochemistry: Simultaneous electrochemical detection at multiple working conditions in a paper-based analytical device.Analytica chimica acta · 2019Article
- Rapid Drop-Test for Lectin Binding with Glycopolymer-Coated Optical Ring Resonators.Biosensors · 2019Article
- Optical Biosensors Based on Silicon-On-Insulator Ring Resonators: A Review.Molecules (Basel, Switzerland) · 2019Review
- Silicon Photonic Biosensors Using Label-Free Detection.Sensors (Basel, Switzerland) · 2018Review
- A Guide to Quantitative Biomarker Assay Development using Whispering Gallery Mode Biosensors.Current protocols in chemical biology · 2017Article
- Whispering-Gallery Mode Resonators for Detecting Cancer.Sensors (Basel, Switzerland) · 2017Review
- Label-Free Biological and Chemical Sensing Using Whispering Gallery Mode Optical Resonators: Past, Present, and Future.Sensors (Basel, Switzerland) · 2017Review
- Emerging Cytokine Biosensors with Optical Detection Modalities and Nanomaterial-Enabled Signal Enhancement.Sensors (Basel, Switzerland) · 2017Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Because of the inherent complexity of biochemical pathways commonly altered in disease states, it has become accepted that multiplexed analyses can provide a more informative biomolecular understanding of disease onset and progression. Importantly, compared to conventional single-parameter assays, the detailed biomolecular insight gleaned from multiparameter measurements has the potential to greatly improve disease diagnostics, prognostics, and theragnostics. We have previously reported the utility of silicon photonic microring resonators for the sensitive quantitation of a single disease biomarker and herein demonstrate the first example of optical microcavity resonator arrays performing quantitative, label-free, multiplexed analyses of clinically relevant protein biomarkers. In this report, the concentrations of prostate specific antigen (PSA), alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8) are simultaneously determined in three unknown protein cocktail solutions. This letter demonstrates that multiple immunoassays can be performed concurrently on a microresonator platform without any accompanying loss of sensitivity or measurement precision, and therefore, this report lays the groundwork for future applications involving multiplexed analysis of clinically relevant samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.