ArticleGlia2010
Olfactory ensheathing cell membrane properties are shaped by connectivity.
Article in Glia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- High iron in mouse olfactory ensheathing cells at the glia limitans in the olfactory bulb underlies MRI TImaging neuroscience (Cambridge, Mass.) · 2024Article
- On the electrical passivity of astrocyte potassium conductance.Journal of neurophysiology · 2021Review
- An Evolutionary Microcircuit Approach to the Neural Basis of High Dimensional Sensory Processing in Olfaction.Frontiers in cellular neuroscience · 2021Article
- Article
- Selective Cre-mediated gene deletion identifies connexin 43 as the main connexin channel supporting olfactory ensheathing cell networks.The Journal of comparative neurology · 2019Article
- AMPA Receptor-Mediated CaFrontiers in cellular neuroscience · 2019Article
- Tumoricidal effect of human olfactory ensheathing cell mediated suicide gene therapy in human glioblastoma cells.Molecular biology reports · 2018Article
- Conditioned Media From Glial Cells Promote a Neural-Like Connexin Expression in Human Adipose-Derived Mesenchymal Stem Cells.Frontiers in physiology · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Cell migration in the developing rodent olfactory system.Cellular and molecular life sciences : CMLS · 2016Review
- Electrophysiological behavior of neonatal astrocytes in hippocampal stratum radiatum.Molecular brain · 2016Article
- Voltage-dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells.Glia · 2015Article
- Freshly dissociated mature hippocampal astrocytes exhibit passive membrane conductance and low membrane resistance similarly to syncytial coupled astrocytes.Journal of neurophysiology · 2015Article
- Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer.The Journal of comparative neurology · 2015Article
- Glutamate mediated astrocytic filtering of neuronal activity.PLoS computational biology · 2014Article
- Anatomy and cellular constituents of the human olfactory mucosa: a review.Journal of neurological surgery. Part B, Skull base · 2014Article
- Immunocytochemical characterisation of olfactory ensheathing cells of zebrafish.Journal of anatomy · 2014Article
- Sparse short-distance connections enhance calcium wave propagation in a 3D model of astrocyte networks.Frontiers in computational neuroscience · 2014Article
- Patterns of heterogeneous expression of pannexin 1 and pannexin 2 transcripts in the olfactory epithelium and olfactory bulb.Journal of molecular histology · 2012Article
- Connexin and AMPA receptor expression changes over time in the rat olfactory bulb.Neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Olfactory ensheathing cells (OECs) have been repeatedly implicated in mediating plasticity, particularly in situ in the olfactory nerve in which they support the extension of olfactory sensory neuron (OSN) axons from the olfactory epithelium to the olfactory bulb (OB). OECs are specialized glia whose processes surround OSN axon fascicles within the olfactory nerve and across the OB surface. Despite their purported importance in promoting axon extension, and following transplants, little is known about either morphology or biophysical properties of OECs in situ. In particular, cell-cell interactions that may influence OEC function are largely unexplored. Here, we studied OEC connectivity and morphology in slice preparations, preserving tissue structure and cell-cell interactions. Our analyses showed that OECs form a matrix of cellular projections surrounding axons, unique among glia, and express high levels of connexin-43. Lucifer Yellow injections revealed selective dye coupling among small subgroups of OECs. Two types of OECs were biophysically distinguished with whole-cell voltage-clamp recordings: (1) with low-input resistance (R(i)), linear current profiles, and frequently dye coupled; and (2) with high R(i), nonlinear current profiles, and infrequent dye coupling. Pharmacological blockade of gap junctions changed OEC membrane properties such that linear OECs became nonlinear. Double recordings indicated that the appearance of the nonlinear current profile was associated with the loss of electrical coupling between OECs. We conclude that the diversity of OEC current profiles can be explained by differences in gap-junction connectivity and discuss implications of this diversity for OEC influences on axon growth and excitability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.