ArticleInternational journal of cancer2010
Dietary fatty acids, luminal modifiers, and risk of colorectal cancer.
Article in International journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Dietary intake and tissue biomarkers of omega-6 fatty acids and risk of colorectal cancer in adults: a systematic review and dose-response meta-analysis of prospective cohort studies.Nutrition & diabetes · 2025Pooled it
- Dietary trans fatty acids and risk of colorectal cancer: a systematic review and meta-analysis of observational studies.European journal of nutrition · 2023Pooled it
- Omega-3 PUFA intake and the risk of digestive system cancers: A meta-analysis of observational studies.Medicine · 2020Pooled it
- Article
- Dietary Omega Polyunsaturated Fatty Acid Intake and Patient-Reported Outcomes in Systemic Lupus Erythematosus: The Michigan Lupus Epidemiology and Surveillance Program.Arthritis care & research · 2020Article
- Global Plasma Profiling for Colorectal Cancer-Associated Volatile Organic Compounds: a Proof-of-Principle Study.Journal of chromatographic science · 2019Article
- Nutritional Correlates of Human Oral Microbiome.Journal of the American College of Nutrition · 2017Article
- Diet, microorganisms and their metabolites, and colon cancer.Nature reviews. Gastroenterology & hepatology · 2016Review
- The Interaction between Dietary Fiber and Fat and Risk of Colorectal Cancer in the Women's Health Initiative.Nutrients · 2016Article
- In vitro fermentation of nuts results in the formation of butyrate and c9,t11 conjugated linoleic acid as chemopreventive metabolites.European journal of nutrition · 2016Article
- Differential effects of patient-related factors on the outcome of radiation therapy for rectal cancer.Journal of radiation oncology · 2016Article
- Lipidome in colorectal cancer.Oncotarget · 2016Review
- Impact of Dietary Lipids on Colonic Function and Microbiota: An Experimental Approach Involving Orlistat-Induced Fat Malabsorption in Human Volunteers.Clinical and translational gastroenterology · 2016Article
- Colorectal carcinogenesis--update and perspectives.World journal of gastroenterology · 2014Review
- Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing type 2 diabetes, cardiovascular diseases, and cancer: a systematic review.Food & nutrition research · 2014Review
- Long-chain omega-3 polyunsaturated fatty acid intake and risk of colorectal cancer.Nutrition and cancer · 2014Article
- Partial associations of dietary iron, smoking and intestinal bacteria with colorectal cancer risk.Nutrition and cancer · 2013Article
- Fatty acids in habitual diet, plasma phospholipids, and tumour and normal colonic biopsies in young colorectal cancer patients.Journal of oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Inconsistent observations in epidemiologic studies on the association between total fat intake and colorectal cancer may be ascribed to opposing effects of individual fatty acids and the presence of other dietary constituents that modify luminal or systemic lipid exposure. We analyzed the data from a population-based case-control study that included 1,163 cases and 1,501 controls to examine the effects of individual fatty acid groups on colorectal cancer risk as well as their interactions with calcium and fiber intake. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression model according to quartile levels of energy-adjusted fatty acid intake. In the bivariable analyses, the risk of colorectal cancer increased with trans fatty acid (TFA) intake (OR for top vs. bottom quartile =1.46, 95% CI 1.17-1.59, p-value for a trend <0.001), but the associations was substantially attenuated in multivariable analyses (p value for a trend = 0.176). However, a significant linear trend in the multivariable OR (p = 0.029) for TFA was present for subjects with lower calcium intake. Furthermore, multivariable ORs progressively decreased with increasing both omega-3 and omega-6 poly- unsaturated fatty acid intake (p-values for linear trend: 0.033 and 0.011, respectively) for subjects with lower dietary fiber intake. These interactions were also significant or marginally significant (p = 0.085 for TFA, 0.029 for omega-3 and 0.068 for omega-6). Our results suggest that populations with lower intake of luminal modifiers, i.e., calcium and fiber, may have differential risks of colorectal cancer associated with dietary fatty acid intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.