ArticleWorld journal of surgery2010
Breast cancer in young women in a limited-resource environment.
Article in World journal of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Survival Patterns Among Patients With Breast Cancer in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Stage at diagnosis of breast cancer in sub-Saharan Africa: a systematic review and meta-analysis.The Lancet. Global health · 2016Pooled it
- Receptor-defined subtypes of breast cancer in indigenous populations in Africa: a systematic review and meta-analysis.PLoS medicine · 2014Pooled it
- Comprehensive Review of Breast Cancer Consequences for the Patients and Their Coping Strategies: A Systematic Review.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Survival deficits in young women with breast cancer in sub-Saharan Africa: the African Breast Cancer-Disparities in Outcomes cohort.Journal of the National Cancer Institute · 2025Article
- Stage at diagnosis and tumor characteristics among young women and men with breast cancer, in Ethiopia and Sweden, a descriptive cross-sectional study.BMC cancer · 2025Article
- Global burden and attributable risk factors of breast cancer in young women: historical trends from 1990 to 2019 and forecasts to 2030 by sociodemographic index regions and countries.Journal of global health · 2024Article
- Article
- Breast cancer in sub-Saharan Africa: The current state and uncertain future.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Young Women with Breast Cancer in Resource-Limited Settings: What We Know and What We Need to Do Better.Breast cancer (Dove Medical Press) · 2021Review
- Breast cancer molecular subtypes and receptor status among women at Potchefstroom Hospital: a cross-sectional study.The Pan African medical journal · 2021Article
- Epidemiological, clinical and diagnostic profile of breast cancer patients treated at Potchefstroom regional hospital, South Africa, 2012-2018: an open-cohort study.The Pan African medical journal · 2020Article
- Socio-demographic, pattern of presentation and management outcome of breast cancer in a semi-urban tertiary health institution.The Pan African medical journal · 2020Article
- Improving early detection of breast cancer in sub-Saharan Africa: why mammography may not be the way forward.Globalization and health · 2019Review
- Article
- Breast Cancer Knowledge, Behaviors, and Preferences in Malawi: Implications for Early Detection Interventions From a Discrete Choice Experiment.Journal of global oncology · 2017Article
- Surgical Management of Breast Cancer in Africa: A Continent-Wide Review of Intervention Practices, Barriers to Care, and Adjuvant Therapy.Journal of global oncology · 2017Review
- Sociocultural factors and breast cancer in sub-Saharan Africa: implications for diagnosis and management.Women's health (London, England) · 2016Article
- From the set-up of a screening program of breast cancer patients to the identification of the first BRCA mutation in the DR Congo.BMC public health · 2014Article
- Integrating genetic and genomic information into effective cancer care in diverse populations.Annals of oncology : official journal of the European Society for Medical Oncology · 2013Article
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Abstract
backgroundDespite the higher incidence of breast cancer in young women in developing countries, there is a paucity of data on their management. We present the clinicopathological features and outcome of treatment of women 35 years or younger with breast cancer in a resource-restricted environment.
methodsA total of 141 patients who were diagnosed with primary breast cancer at 35 years or younger from January 2000 to June 2008 were retrieved from the cancer registry of a breast clinic at a tertiary hospital and a private breast health center in South Africa. Clinicopathological features, treatment, and survival were analyzed.
resultsTwo patients presented with TNM stage 0 (1.4%), 14 with stage I (9.9%), 47 with stage II (33.35%), 47 with stage III (33.3%), and 31 with stage IV (21.9%). Tumor grade was 3 in 47%, grade 2 in 37%, and grade 1 in 16% of patients. One hundred and four patients with stage 0-III disease underwent treatment with curative intent, 83 had a mastectomy, and 12 had breast-conserving surgery. Ninety patients (86.5%) had chemotherapy, 68 (65.4%) had radiotherapy, and 50 (48.1%) had hormonal therapy. Of 93 patients who completed primary therapy, 4 developed contralateral cancers, 3 had locoregional recurrence, 8 developed synchronous locoregional and distant recurrence, and 19 relapsed with distant metastasis only. The 2-year disease-free and overall survival for stage 0-III disease was 48 and 56%, respectively.
conclusionsYoung women with breast cancer in a resource-limited environment have similar adverse clinicopathological features to those in developed countries. Their disease is more advanced at presentation with poorer outcome. Increased awareness, better systemic therapy, and more comprehensive genetic studies are essential to improve the dismal outcome.
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