ArticlePsychopharmacology2010
Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Are cannabis-using and non-using patients different groups? Towards understanding the neurobiology of cannabis use in psychotic disorders.Journal of psychopharmacology (Oxford, England) · 2018Pooled it
- Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence.European archives of psychiatry and clinical neuroscience · 2013Pooled it
- Effects of cannabis use on human brain structure in psychosis: a systematic review combining in vivo structural neuroimaging and post mortem studies.Current pharmaceutical design · 2012Pooled it
- Cannabis use disorder: from neurobiology to treatment.The Journal of clinical investigation · 2024Review
- Neuromodulation for Cannabis Use: A Scoping Review.Brain sciences · 2024Article
- Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia.Translational psychiatry · 2021Review
- The Influence of Recreational Substance Use in TMS Research.Brain sciences · 2020Review
- Association of cannabis with glutamatergic levels in patients with early psychosis: Evidence for altered volume striatal glutamate relationships in patients with a history of cannabis use in early psychosis.Translational psychiatry · 2020Article
- Test-retest reliability of short-interval intracortical inhibition and intracortical facilitation in patients with schizophrenia.Psychiatry research · 2018Article
- Investigating Cortical Inhibition in First-Degree Relatives and Probands in Schizophrenia.Scientific reports · 2017Article
- GABA abnormalities in schizophrenia: a methodological review of in vivo studies.Schizophrenia research · 2015Review
- Evidence for inhibitory deficits in the prefrontal cortex in schizophrenia.Brain : a journal of neurology · 2015Article
- BDNF-Val66Met-polymorphism impact on cortical plasticity in schizophrenia patients: a proof-of-concept study.The international journal of neuropsychopharmacology · 2014Article
- Cortical inhibition, excitation, and connectivity in schizophrenia: a review of insights from transcranial magnetic stimulation.Schizophrenia bulletin · 2014Review
- Cannabis-related working memory deficits and associated subcortical morphological differences in healthy individuals and schizophrenia subjects.Schizophrenia bulletin · 2014Article
- Individualized brain inhibition and excitation profile in response to paired-pulse TMS.Journal of motor behavior · 2014Article
- Modulating neural plasticity with non-invasive brain stimulation in schizophrenia.European archives of psychiatry and clinical neuroscience · 2013Review
- Inhibition of the cortex using transcranial magnetic stimulation in psychiatric populations: current and future directions.Journal of psychiatry & neuroscience : JPN · 2012Review
- Interneuron dysfunction in psychiatric disorders.Nature reviews. Neuroscience · 2012Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE/
objectivesThere is a high prevalence of substance use disorder (SUD) in first-episode schizophrenia (SZ), but its contribution to the underlying SZ pathophysiology remains unclear. Several studies using transcranial magnetic stimulation (TMS) have observed abnormalities in human motor cortex (M1) excitability in SZ. Studies on cortical excitability comparing SZ patients with and without comorbid substance abuse are lacking.
methodsA total of 29 first-episode SZ patients participated in this study; 12 had a history of comorbid cannabis abuse (SZ-SUD) and 17 did not (SZ-NSUD). We applied TMS to right and left M1 areas to assess the resting motor threshold (RMT), short-interval cortical inhibition (SICI), intracortical facilitation (ICF), and the contralateral cortical silent period (CSP).
resultsIn SICI and ICF conditions, right M1 stimulation led to significantly higher motor evoked potential ratios in SZ-SUD compared to SZ-NSUD. This suggests lower cortical inhibition and increased ICF in first-episode SZ with previous cannabis abuse. There were no group differences in RMT and CSP duration. Neither were there any significant correlations between psychopathology (as indexed by Positive and Negative Syndrome Scale), disease characteristics, the extent of cannabis abuse, and TMS parameters (SICI, ICF, and CSP).
conclusionsComorbid cannabis abuse may potentiate the reduced intracortical inhibition and enhanced ICF observed in first-episode SZ patients in some previous studies. This finding suggests an increased alteration of GABA(A) and NMDA receptor activity in cannabis-abusing first-episode patients as compared to schizophrenia patients with no history of substance abuse. This may constitute a distinct vulnerability factor in this special population.
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Registered trials
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