ArticlePloS one2009
Seasonal differences of gene expression profiles in song sparrow (Melospiza melodia) hypothalamus in relation to territorial aggression.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Dissecting the Transcriptional Patterns of Social Dominance across Teleosts.Integrative and comparative biology · 2016Pooled it
- Brain transcriptomics of a social challenge and maternal aggression in incubating female tree swallows.Hormones and behavior · 2025Article
- Social boldness correlates with brain gene expression in male green anoles.Hormones and behavior · 2021Article
- µ-Crystallin: A thyroid hormone binding protein.Endocrine regulations · 2021Review
- Experimental competition induces immediate and lasting effects on the neurogenome in free-living female birds.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Neuroendocrine Mechanisms Underlying Non-breeding Aggression: Common Strategies Between Birds and Fish.Frontiers in neural circuits · 2021Review
- Sex-and Region-Dependent Expression of the Autism-Linked ADNP Correlates with Social- and Speech-Related Genes in the Canary Brain.Journal of molecular neuroscience : MN · 2020Article
- Brain transcriptomics of agonistic behaviour in the weakly electric fish Gymnotus omarorum, a wild teleost model of non-breeding aggression.Scientific reports · 2020Article
- The neurogenomic transition from territory establishment to parenting in a territorial female songbird.BMC genomics · 2019Article
- A chromosomal inversion predicts the expression of sex steroid-related genes in a species with alternative behavioral phenotypes.Molecular and cellular endocrinology · 2019Article
- Rapid effects of 17β-estradiol on aggressive behavior in songbirds: Environmental and genetic influences.Hormones and behavior · 2018Review
- Biological Clocks and Rhythms of Anger and Aggression.Frontiers in behavioral neuroscience · 2018Review
- Socially cued seminal fluid gene expression mediates responses in ejaculate quality to sperm competition risk.Proceedings. Biological sciences · 2017Article
- Molecular mechanisms and the conflict between courtship and aggression in three-spined sticklebacks.Molecular ecology · 2016Article
- A review of the peripheral levels of regulation by thyroid hormone.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Assessment of fight outcome is needed to activate socially driven transcriptional changes in the zebrafish brain.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Validation of Reference Genes for Quantitative Real-Time PCR in Bovine PBMCs Transformed and Non-transformed by Theileria annulata.The Korean journal of parasitology · 2016Article
- Natural variation in brain gene expression profiles of aggressive and nonaggressive individual sticklebacks.Behaviour · 2016Article
- Genes located in a chromosomal inversion are correlated with territorial song in white-throated sparrows.Genes, brain, and behavior · 2015Article
- Rapid Effects of Estradiol on Aggression in Birds and Mice: The Fast and the Furious.Integrative and comparative biology · 2015Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMale song sparrows (Melospiza melodia) are territorial year-round; however, neuroendocrine responses to simulated territorial intrusion (STI) differ between breeding (spring) and non-breeding seasons (autumn). In spring, exposure to STI leads to increases in luteinizing hormone and testosterone, but not in autumn. These observations suggest that there are fundamental differences in the mechanisms driving neuroendocrine responses to STI between seasons. Microarrays, spotted with EST cDNA clones of zebra finch, were used to explore gene expression profiles in the hypothalamus after territorial aggression in two different seasons. METHODOLOGY/PRINCIPAL
findingsFree-living territorial male song sparrows were exposed to either conspecific or heterospecific (control) males in an STI in spring and autumn. Behavioral data were recorded, whole hypothalami were collected, and microarray hybridizations were performed. Quantitative PCR was performed for validation. Our results show 262 cDNAs were differentially expressed between spring and autumn in the control birds. There were 173 cDNAs significantly affected by STI in autumn; however, only 67 were significantly affected by STI in spring. There were 88 cDNAs that showed significant interactions in both season and STI. CONCLUSIONS/SIGNIFICANCE: Results suggest that STI drives differential genomic responses in the hypothalamus in the spring vs. autumn. The number of cDNAs differentially expressed in relation to season was greater than in relation to social interactions, suggesting major underlying seasonal effects in the hypothalamus which may determine the differential response upon social interaction. Functional pathway analyses implicated genes that regulate thyroid hormone action and neuroplasticity as targets of this neuroendocrine regulation.
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