Evidence map›Paper›PMID 19997522›Full record

ArticleJournal of neurodevelopmental disorders2009

Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment.

Mabel L Rice, Shelley D Smith, Javier Gayán

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurodevelopmental disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 124 citations in OpenAlex.

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  16. The Finite Verb Morphology Composite: Values From a Community Sample.Journal of speech, language, and hearing research : JSLHR · 2019
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Mabel L Rice
Shelley D Smith
Javier Gayán
University of Kansas · USUniversity of Nebraska Medical Center · US

Funding

MORPHOSYNTACTIC ABILITIES OF SLI PROBANDS AND FAMILIESR01DC001803 · NIDCD · UNIVERSITY OF KANSAS LAWRENCE · PI RICE, MABEL L · 1993 to 2022
$10.9M
Twins and Singletons with Specific Language ImpairmentR01DC005226 · NIDCD · UNIVERSITY OF KANSAS LAWRENCE · PI RICE, MABEL L · 2002 to 2016
$8.3M
NIDCD NIH HHS R01 DC001803NIDCD NIH HHS R01 DC005226
6 · The paper itself

Abstract

unlabelledWe analyzed genetic linkage and association of measures of language, speech and reading phenotypes to candidate regions in a single set of families ascertained for SLI. Sib-pair and family-based analyses were carried out for candidate gene loci for Reading Disability (RD) on chromosomes 1p36, 3p12-q13, 6p22, and 15q21, and the speech-language candidate region on 7q31 in a sample of 322 participants ascertained for Specific Language Impairment (SLI). Replication or suggestive replication of linkage was obtained in all of these regions, but the evidence suggests that the genetic influences may not be identical for the three domains. In particular, linkage analysis replicated the influence of genes on chromosome 6p for all three domains, but association analysis indicated that only one of the candidate genes for reading disability, KIAA0319, had a strong effect on language phenotypes. The findings are consistent with a multiple gene model of the comorbidity between language impairments and reading disability and have implications for neurocognitive developmental models and maturational processes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-009-9031-x) contains supplementary material, which is available to authorized users.

Indexed as

Gene associationsGene linkageLanguage impairmentsLanguage, reading, speech phenotypesSpecific language impairment

Identifiers

PMID19997522
PMCPMC2788915
OpenAlexW2131141565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.