ArticleBritish journal of cancer2010
Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells.
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 91 citations in OpenAlex.
- Distinct metabolic dependency on BCAA defines cancer stemness and malignancy in human triple-negative breast cancer.Cell reports · 2026Article
- Enhancer of zeste 2 polycomb repressive complex 2 subunit overexpression suppresses apoptosis in canine T-cell lymphoma: anFrontiers in veterinary science · 2026Article
- PHLDA1 is a P53 target gene involved in P53-mediated cell apoptosis.Molecular and cellular biochemistry · 2024Article
- Addressing erroneous scale assumptions in microbe and gene set enrichment analysis.PLoS computational biology · 2023Article
- Review
- Investigating the evolution process of lung adenocarcinoma via random walk and dynamic network analysis.Frontiers in genetics · 2022Article
- LncRNA MALAT1 regulates METTL3-mediated PD-L1 expression and immune infiltrates in pancreatic cancer.Frontiers in oncology · 2022Article
- Integrative Analysis of Next-Generation Sequencing for Next-Generation Cancer Research toward Artificial Intelligence.Cancers · 2021Review
- Anticancer Activity of Novel NF-kappa B Inhibitor DHMEQ by Intraperitoneal Administration.Oncology research · 2020Review
- The inhibition of MARK2 suppresses cisplatin resistance of osteosarcoma stem cells by regulating DNA damage and repair.Journal of bone oncology · 2020Article
- Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches.Cancer cell international · 2020Review
- Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy.Frontiers in endocrinology · 2019Review
- FGFR signaling regulates resistance of head and neck cancer stem cells to cisplatin.Oncotarget · 2018Article
- Metastatic ability and the epithelial-mesenchymal transition in induced cancer stem-like hepatoma cells.Cancer science · 2018Article
- The role of NF-κB and miRNA in oral cancer and cancer stem cells with or without HPV16 infection.PloS one · 2018Article
- An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells.Oncotarget · 2017Article
- Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells.Oncogene · 2017Article
- Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer.NPJ breast cancer · 2017Article
- Article
- Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer.Cancer science · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTumour-initiating cells (TICs) or cancer stem cells can exist as a small population in malignant tissues. The signalling pathways activated in TICs that contribute to tumourigenesis are not fully understood.
methodsSeveral breast cancer cell lines were sorted with CD24 and CD44, known markers for enrichment of breast cancer TICs. Tumourigenesis was analysed using sorted cells and total RNA was subjected to gene expression profiling and gene set enrichment analysis (GSEA).
resultsWe showed that several breast cancer cell lines have a small population of CD24(-/low)/CD44(+) cells in which TICs may be enriched, and confirmed the properties of TICs in a xenograft model. GSEA revealed that CD24(-/low)/CD44(+) cell populations are enriched for genes involved in transforming growth factor-beta, tumour necrosis factor, and interferon response pathways. Moreover, we found the presence of nuclear factor-kappaB (NF-kappaB) activity in CD24(-/low)/CD44(+) cells, which was previously unrecognised. In addition, NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) prevented tumourigenesis of CD24(-/low)/CD44(+) cells in vivo.
conclusionOur findings suggest that signalling pathways identified using GSEA help to identify molecular targets and biomarkers for TIC-like cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.