ArticleBritish journal of cancer2010
Human papillomavirus infection and squamous cell carcinoma of the conjunctiva.
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Epidemiology of ocular surface squamous neoplasia in Africa.Tropical medicine & international health : TM & IH · 2013Pooled it
- HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis.British journal of cancer · 2013Pooled it
- Interventions for squamous cell carcinoma of the conjunctiva in HIV-infected individuals.The Cochrane database of systematic reviews · 2013Pooled it
- Novel automated non-invasive detection of ocular surface squamous neoplasia using artificial intelligence.World journal of methodology · 2024Review
- Epstein-Barr Virus DNA Is Associated With Conjunctival Squamous Cell Carcinomas: A Case-Control Study From Zimbabwe.Open forum infectious diseases · 2024Article
- HPV-Associated Squamous Cell Carcinoma of the Eyelid: Diagnostic Utility of p16 Immunohistochemistry and mRNA In Situ Hybridization.Head and neck pathology · 2023Article
- Prevalence of human papillomavirus in eyelid carcinoma among Koreans: a clinicopathological study.BMC ophthalmology · 2023Article
- The Management of Ocular Surface Squamous Neoplasia (OSSN).International journal of molecular sciences · 2022Review
- Epstein-Barr Virus, But Not Human Papillomavirus, Is Associated With Preinvasive and Invasive Ocular Surface Squamous Neoplasias in Zambian Patients.Frontiers in oncology · 2022Article
- Review
- Update on the Management of Ocular Surface Squamous Neoplasia.Current ophthalmology reports · 2021Article
- Article
- p16 Expression Correlates with Invasive Ocular Surface Squamous Neoplasms in HIV-Infected Mozambicans.Ocular oncology and pathology · 2020Article
- Observational
- Human papillomavirus infection and ocular surface disease (Review).International journal of oncology · 2019Review
- Ocular surface squamous neoplasia in HIV-infected patients: current perspectives.HIV/AIDS (Auckland, N.Z.) · 2018Review
- Human Papilloma Virus Vaccination and Incidence of Ocular Surface Squamous Neoplasia.International ophthalmology clinics · 2017Review
- Risk factors for ocular surface squamous neoplasia in Kenya: a case-control study.Tropical medicine & international health : TM & IH · 2016Article
- Altered gene expression in conjunctival squamous cell carcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- p16INK4A expression is frequently increased in periorbital and ocular squamous lesions.Diagnostic pathology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSquamous cell carcinoma of the conjunctiva (SCCC) is associated with HIV-related immunosuppression, but human papillomavirus virus (HPV) is also suspected to have a role. We carried out a case-control study to assess the role of cutaneous and mucosal HPV types in SCCC, conjunctival dysplasia, and their combination (SCCC/dysplasia) in Uganda.
methodsWe compared HPV prevalence in frozen biopsies from 94 SCCC cases (79 of whom were found to be HIV-positive), 39 dysplasia cases (34 HIV-positive), and 285 hospital controls (128 HIV-positive) having other eye conditions that required surgery. Highly sensitive PCR assays that detect 75 HPV types were used. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed, adjusting for, or stratifying by age, sex, and HIV status.
resultsCutaneous HPV types were detected in 45% of SCCC cases, 41% of dysplasia cases and 11% of controls. Human papillomavirus virus 5 and 8 were the most common types in SCCC, and most often occurred in combination with other types. Associations were observed between SCCC/dysplasia and detection of both single (OR=2.3; 1.2-4.4) and multiple (OR=18.3; 6.2-54.4) cutaneous HPV types, and were chiefly based on findings in HIV-positive patients. Cutaneous HPV infections were rarely observed among HIV-negative patients and the association with SCCC/dysplasia was not significant (OR=2.4; 0.6-9.6) among them. Squamous cell carcinoma of the conjunctiva/dysplasia risk and mucosal HPV types were not associated in either HIV-positive or HIV-negative patients.
conclusionsWe detected cutaneous HPV types in nearly half of SCCC/dysplasia cases and often multiple types (HPV5 and 8 being most common). The role of HIV (confounder or strong enhancer of cutaneous HPV carcinogenicity) is still uncertain.
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