ReviewNature reviews. Urology2010
The role of testosterone in erectile dysfunction.
Review in Nature reviews. Urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 170 citations in OpenAlex.
- The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis.American journal of men's healthPooled it
- Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.Psychological medicine · 2012Trial
- Effect of vardenafil in long-standing diabetic patients comparing different doses regarding erectile dysfunction, testosterone level and partner satisfaction.Arab journal of urology · 2026Article
- Reproductive dysfunction in hemodialysis: endocrine mechanisms, clinical features, and therapeutic approaches.Renal failure · 2025Review
- COVID-19 infection may reduce serum testosterone levels and increase the risk of erectile dysfunction: A two-sample Mendelian randomization study.Investigative and clinical urology · 2025Article
- Understanding the intricate impacts and mechanism of actions of adaptogens on reproductive function.Cell biochemistry and biophysics · 2025Review
- The role of acupuncture in treating premature ejaculation and its probable neurobiological mechanism.Basic and clinical andrology · 2024Review
- The value of shear wave elastography combined with red blood cell distribution width in evaluating arterial erectile dysfunction.BMC urology · 2024Article
- Clomiphene Citrate Treatment as an Alternative Therapeutic Approach for Male Hypogonadism: Mechanisms and Clinical Implications.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Association between sex hormones and erectile dysfunction in men without hypoandrogenism.Scientific reports · 2024Article
- Review
- A comprehensive analysis of erectile dysfunction prevalence and the impact of prostate conditions on ED among US adults: evidence from NHANES 2001-2004.Frontiers in endocrinology · 2024Observational
- Can we rely on total testosterone measurement to exclude hypogonadism in erectile dysfunction?International journal of impotence research · 2023Article
- Comparison of preoperative penile elastographic ultrasound findings and pathological tissue results of patients implemented with penile prosthesis.Journal of ultrasound · 2023Article
- The role of testosterone in male sexual function.Reviews in endocrine & metabolic disorders · 2022Review
- Microsurgical Management of Male Infertility: Compelling Evidence That Collaboration with Qualified Male Reproductive Urologists Enhances Assisted Reproductive Technology (ART) Outcomes.Journal of clinical medicine · 2022Review
- Estradiol-Testosterone Imbalance Is Associated with Erectile Dysfunction in Patients with Klinefelter Syndrome.Journal of clinical medicine · 2021Article
- Construction and internal validation of a prediction nomogram for acquired premature ejaculation (APE) in PE patients.Andrology · 2021Observational
- Edible Bird's Nest: The Functional Values of the Prized Animal-Based Bioproduct From Southeast Asia-A Review.Frontiers in pharmacology · 2021Review
- Current stepwise recommendations for hypogonadism screening in erectile dysfunction are not cost-effective.International journal of impotence research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erectile dysfunction (ED) is a clinical disorder that results from a continuous spectrum of clinical factors, including physical illness (comprising the organic component of ED), reaction to stress (the intrapsychic component of ED) and relationship difficulties (the relationship component of ED). Testosterone clearly has a relevant role in all three causes of ED; the usefulness of this hormone in the treatment of ED has not, however, been completely clarified. The main physiological action of testosterone in the male sexual response is to regulate the timing of the erectile process as a function of sexual desire, thereby coordinating penile erection with sex. The link between ED, hypogonadism and underlying disorders (such as metabolic syndrome and type 2 diabetes mellitus) is nowadays well documented. The recognition of underlying disorders might be useful in motivating men with ED to improve their health-related lifestyle choices. Hence, patients with ED might be considered 'lucky', because their disorder offers the opportunity to undergo medical examinations to detect underlying disease. Both ED and hypogonadism are treatable conditions. A range of testosterone preparations are available for supplementation; their combination with phosphodiesterase 5 inhibitors might improve outcomes in some cases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.