ArticleThe Journal of biological chemistry2010
Fcgamma receptor cross-linking stimulates cell proliferation of macrophages via the ERK pathway.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from old hosts against antibody-opsonized Streptococcus pneumoniae.Journal of leukocyte biology · 2026Article
- CD300ld promotes neutrophil bacterial phagocytosis in sepsis.Journal of leukocyte biology · 2025Article
- Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond.Current issues in molecular biology · 2024Review
- Detection and functional resolution of soluble immune complexes by an FcγR reporter cell panel.EMBO molecular medicine · 2022Article
- Cyclic Attractors Are Critical for Macrophage Differentiation, Heterogeneity, and Plasticity.Frontiers in molecular biosciences · 2022Article
- Spatially Resolved Analytical Chemistry in Intact, Living Tissues.Analytical chemistry · 2020Review
- LncRNAScience advances · 2019Article
- CD14 Counterregulates Lipopolysacharide-Induced Tumor Necrosis Factor-α Production in a Macrophage Subset.Journal of innate immunity · 2019Article
- Immune-enhancing activity of C. militaris fermented with Pediococcus pentosaceus (GRC-ON89A) in CY-induced immunosuppressed model.BMC complementary and alternative medicine · 2018Article
- Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes.PloS one · 2018Article
- Gene Regulatory Network Modeling of Macrophage Differentiation Corroborates the Continuum Hypothesis of Polarization States.Frontiers in physiology · 2018Article
- Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization.Oncotarget · 2017Article
- A Novel System for the Quantification of the ADCC Activity of Therapeutic Antibodies.Journal of immunology research · 2017Article
- Anti-Nogo-A Immunotherapy Does Not Alter Hippocampal Neurogenesis after Stroke in Adult Rats.Frontiers in neuroscience · 2016Article
- Keyhole limpet hemocyanin induces innate immunity via Syk and Erk phosphorylation.EXCLI journal · 2016Article
- Fcγ receptors and ligands and cardiovascular disease.Circulation research · 2015Review
- Targeting spleen tyrosine kinase-Bruton's tyrosine kinase axis for immunologically mediated glomerulonephritis.BioMed research international · 2014Review
- TLR2 deletion promotes arthritis through reduction of IL-10.Journal of leukocyte biology · 2013Article
- Analysis of cell cycle and replication of mouse macrophages after in vivo and in vitro Cryptococcus neoformans infection using laser scanning cytometry.Infection and immunity · 2012Article
- The Pathogenic Role of the Adaptive Immune Response to Modified LDL in Diabetes.Frontiers in endocrinology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Macrophage proliferation can be stimulated by phagocytosis and by cross-linking of Fcgamma receptors (FcgammaR). In this study, we investigated the role of FcgammaR and the signaling cascades that link FcgammaR activation to cell cycle progression. This effect was mediated by the activating FcgammaR, including FcgammaRI and III, via their Fcgamma subunit. Further investigation revealed that the cell cycle machinery was activated by FcgammaR cross-linking through downstream signaling events. Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol. Our findings establish a link between the ERK activation and cell cycle signaling pathways, thus providing a causal mechanism by which FcgammaR activation produces a mitogenic effect that stimulates macrophage proliferation. Macrophage mitosis following FcgammaR activation could potentially affect the outcome of macrophage interactions with intracellular pathogens. In addition, our results suggest the possibility of new treatment options for certain infectious diseases, chronic inflammatory diseases, and leukemias based on interference with FcgammaR-stimulated macrophage cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.