ArticleProceedings of the National Academy of Sciences of the United States of America2009
Dynamics of the Dorsal morphogen gradient.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed.
- Article
- Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription.Development (Cambridge, England) · 2025Article
- Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription.bioRxiv : the preprint server for biology · 2024Article
- ISRES+: an improved evolutionary strategy for function minimization to estimate the free parameters of systems biology models.Bioinformatics (Oxford, England) · 2023Article
- The epithelial polarity genes frazzled and GUK-holder adjust morphogen gradients to coordinate changes in cell position with cell fate specification.PLoS biology · 2023Article
- SUMOylation of Dorsal attenuates Toll/NF-κB signaling.Genetics · 2022Article
- Pseudocleavage furrows restrict plasma membrane-associated PH domain in syncytial Drosophila embryos.Biophysical journal · 2022Article
- Article
- Temporal integration of inductive cues on the way to gastrulation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Implications of diffusion and time-varying morphogen gradients for the dynamic positioning and precision of bistable gene expression boundaries.PLoS computational biology · 2021Article
- A reaction-diffusion network model predicts a dual role of Cactus/IκB to regulate Dorsal/NFκB nuclear translocation in Drosophila.PLoS computational biology · 2021Article
- Article
- Regulation of spatiotemporal limits of developmental gene expression via enhancer grammar.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Mechanism and implications of morphogen shuttling: Lessons learned from dorsal and Cactus in Drosophila.Developmental biology · 2020Article
- Robustness of the Dorsal morphogen gradient with respect to morphogen dosage.PLoS computational biology · 2020Article
- Self-Similar Dynamics of Nuclear Packing in the Early Drosophila Embryo.Biophysical journal · 2019Article
- The Drosophila Pioneer Factor Zelda Modulates the Nuclear Microenvironment of a Dorsal Target Enhancer to Potentiate Transcriptional Output.Current biology : CB · 2019Article
- Imaging and Quantification of P-Smad1/5 in Zebrafish Blastula and Gastrula Embryos.Methods in molecular biology (Clifton, N.J.) · 2019Article
- The Toll Pathway in the Central Nervous System of Flies and Mammals.Neuromolecular medicine · 2018Review
3 more citing papers are in PubMed but not listed here.
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7 authors.
Funding
Abstract
The dorsoventral (DV) patterning of the Drosophila embryo depends on the nuclear localization gradient of Dorsal (Dl), a protein related to the mammalian NF-kappaB transcription factors. Current understanding of how the Dl gradient works has been derived from studies of its transcriptional interpretation, but the gradient itself has not been quantified. In particular, it is not known whether the Dl gradient is stable or dynamic during the DV patterning of the embryo. To address this question, we developed a mathematical model of the Dl gradient and constrained its parameters by experimental data. Based on our computational analysis, we predict that the Dl gradient is dynamic and, to a first approximation, can be described as a concentration profile with increasing amplitude and constant shape. These time-dependent properties of the Dl gradient are different from those of the Bicoid and MAPK phosphorylation gradients, which pattern the anterior and terminal regions of the embryo. Specifically, the gradient of the nuclear levels of Bicoid is stable, whereas the pattern of MAPK phosphorylation changes in both shape and amplitude. We attribute these striking differences in the dynamics of maternal morphogen gradients to the differences in the initial conditions and chemistries of the anterior, DV, and terminal systems.
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