Gene-environment interactions: biologically valid pathway or artifact?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it.

1. MAOA, childhood maltreatment, and antisocial behavior: meta-analysis of a gene-environment interaction.Biological psychiatry · 2014
   Pooled it
2. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.Molecular psychiatry · 2012
   Pooled it
3. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation.Archives of general psychiatry · 2011
   Pooled it
4. The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants.Development and psychopathology · 2015
   Trial
5. The influence of genetic factors on the severity of anxiety and depressive symptoms and the choice of coping strategies in reproductive tract cancer-a preliminary study.Frontiers in public health · 2025
   Article
6. Extending Previous cG×I Findings on 5-HTTLPR's Moderation of Intervention Effects on Adolescent Substance Misuse Initiation.Child development · 2017
   Article
7. Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis.Depression and anxiety · 2017
   Article
8. The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model.Journal of youth and adolescence · 2016
   Article
9. Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
   Review
10. Looking Forward in Candidate Gene Research: Concerns and Suggestions.Journal of marriage and the family · 2015
    Article
11. Developmental differences in early adolescent aggression: a gene × environment × intervention analysis.Journal of youth and adolescence · 2015
    Article
12. Genotypes do not confer risk for delinquency but rather alter susceptibility to positive and negative environmental factors: gene-environmentinteractions of BDNF Val66Met, 5-HTTLPR, and MAOA-uVNTR [corrected].The international journal of neuropsychopharmacology · 2014
    Article
13. Illness progression as a function of independent and accumulating poor prognosis factors in outpatients with bipolar disorder in the United States.The primary care companion for CNS disorders · 2014
    Article
14. A neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy.Frontiers in behavioral neuroscience · 2014
    Review
15. Vulnerability to depression: a moderated mediation model of the roles of child maltreatment, peer victimization, and serotonin transporter linked polymorphic region genetic variation among children from low socioeconomic status backgrounds.Development and psychopathology · 2013
    Article
16. Contributions of maltreatment and serotonin transporter genotype to depression in childhood, adolescence, and early adulthood.Journal of affective disorders · 2013
    Article
17. Depression in childhood and adolescence.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2013
    Article
18. Ethical, legal, social, and policy implications of behavioral genetics.Annual review of genomics and human genetics · 2013
    Review
19. Molecular-genetic correlates of infant attachment: a cautionary tale.Attachment & human development · 2013
    Article
20. Emerging risk factors for postpartum depression: serotonin transporter genotype and omega-3 fatty acid status.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2012
    Review

Corrections and comments

• Comment on
  Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis.2009

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.