Evidence map›Paper›PMID 19995806›Full record

ArticleThe Journal of heredity

The alpha glycerophosphate cycle in Drosophila melanogaster V. molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.

Amber Carmon, Jeff Chien, David Sullivan, Ross MacIntyre

Abstract read
In one paragraph

Article in The Journal of heredity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amber CarmonDepartment of Molecular Biology and Genetics, 407 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA.
Jeff Chien
David Sullivan
Ross MacIntyre

Funding

LISSTR01AR044534 · NIAMS · SYRACUSE UNIVERSITY · PI SULLIVAN, DAVID T · 1998 to 2002
$1.0M
NIAMS NIH HHS AR 44534
6 · The paper itself

Abstract

Two enzymes, alpha glycerophosphate dehydrogenase (GPDH-1) in the cytoplasm and alpha glycerophosphate oxidase (GPO-1) in the mitochondrion cooperate in Drosophila flight muscles to generate the ATP needed for muscle contraction. Null mutants for either enzyme cannot fly. Here, we characterize 15 ethyl methane sulfonate (EMS)-induced mutants in GPDH-1 at the molecular level and assess their effects on structural and evolutionarily conserved domains of this enzyme. In addition, we molecularly characterize 3 EMS-induced GPO-1 mutants and excisions of a P element insertion in the GPO-1 gene. The latter represent the best candidate for null or amorphic mutants in this gene.

Indexed as

Amino Acid SequenceAnimalsAnimals, Genetically ModifiedDNA Mutational AnalysisDrosophila melanogasterEnzyme ActivationFlight, AnimalGlycerolphosphate DehydrogenaseGlycerophosphatesMolecular Sequence DataMutant ProteinsMutationProtein Structure, Tertiaryalpha-glycerophosphoric acidGlycerolphosphate DehydrogenaseGlycerophosphatesMutant Proteins

Identifiers

PMID19995806
PMCPMC2877542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.