ArticleHuman molecular genetics2010
Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice.
Article in Human molecular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- A haplotype of angiotensin receptor type 1 associated with human hypertension increases blood pressure in transgenic mice.The Journal of biological chemistry · 2013Trial
- Circadian Regulation of Gene Expression and Metabolism in the Liver.Seminars in liver disease · 2022Review
- Genome-wide scan highlights the role of candidate genes on phenotypic plasticity for age at first calving in Nellore heifers.Scientific reports · 2020Article
- Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice.American journal of hypertension · 2018Article
- Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR.FEBS letters · 2018Article
- Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1).The Journal of biological chemistry · 2018Article
- Metabolic Syndrome Induces Over Expression of the Human AT1R: A Haplotype-Dependent Effect With Implications on Cardio-Renal Function.American journal of hypertension · 2018Article
- Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation.Nature communications · 2018Article
- Congenic mice demonstrate the presence of QTLs conferring obesity and hypercholesterolemia on chromosome 1 in the TALLYHO mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol.American journal of human genetics · 2015Article
- Developmental Stage-Specific Hepatocytes Induce Maturation of HepG2 Cells by Rebuilding the Regulatory Circuit.Molecular medicine (Cambridge, Mass.) · 2015Article
- Significant association between upstream transcription factor 1 rs2516839 polymorphism and hepatocellular carcinoma risk: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Sexually-dimorphic targeting of functionally-related genes in COPD.BMC systems biology · 2014Article
- DNA methylation of the LY86 gene is associated with obesity, insulin resistance, and inflammation.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2014Article
- Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque.Scientific reports · 2014Article
- Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Histone deacetylase 9 is a negative regulator of adipogenic differentiation.The Journal of biological chemistry · 2011Article
- Role of the USF1 transcription factor in diabetic kidney disease.American journal of physiology. Renal physiology · 2011Article
- Validation and characterization of DNA microarray gene expression data distribution and associated moments.BMC bioinformatics · 2010Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Upstream transcription factor 1 (USF1) has been associated with familial combined hyperlipidemia, the metabolic syndrome, and related conditions, but the mechanisms involved are unknown. In this study, we report validation of Usf1 as a causal gene of cholesterol homeostasis, insulin sensitivity and body composition in mouse models using several complementary approaches and identify associated pathways and gene expression network modules. Over-expression of human USF1 in both transgenic mice and mice with transient liver-specific over-expression influenced metabolic trait phenotypes, including obesity, total cholesterol level, LDL/VLDL cholesterol and glucose/insulin ratio. Additional analyses of trait and hepatic gene expression data from an F2 population derived from C57BL/6J and C3H/HeJ strains in which there is a naturally occurring variation in Usf1 expression supported a causal role for Usf1 for relevant metabolic traits. Gene network and pathway analyses of the liver gene expression signatures in the F2 population and the hepatic over-expression model suggested the involvement of Usf1 in immune responses and metabolism, including an Igfbp2-centered module. In all three mouse model settings, notable sex specificity was observed, consistent with human studies showing differences in association with USF1 gene polymorphisms between sexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.