ArticleAnnals of clinical microbiology and antimicrobials2009
The occurrence of antimicrobial resistance and class 1 integrons among commensal Escherichia coli isolates from infants and elderly persons.
Article in Annals of clinical microbiology and antimicrobials, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Classes 1 and 2 integrons in faecal Escherichia coli strains isolated from mother-child pairs in Nigeria.PloS one · 2017Article
- Distribution of Integrons and Phylogenetic Groups among EnteropathogenicFrontiers in microbiology · 2017Article
- Exploring the Role of Coliform Bacteria in Class 1 Integron Carriage and Biofilm Formation During Drinking Water Treatment.Microbial ecology · 2016Article
- Distribution of pathogenicity island markers in commensal and uropathogenic Escherichia coli isolates.Folia microbiologica · 2016Article
- Biodiversity of Intestinal Lactic Acid Bacteria in the Healthy Population.Advances in experimental medicine and biology · 2016Review
- The commensal infant gut meta-mobilome as a potential reservoir for persistent multidrug resistance integrons.Scientific reports · 2015Article
- Occurrence of SHV, TEM and CTX-M β-Lactamase Genes Among Enteropathogenic Escherichia coli Strains Isolated From Children With Diarrhea.Jundishapur journal of microbiology · 2015Article
- Integrons: past, present, and future.Microbiology and molecular biology reviews : MMBR · 2014Review
- Integrons in the intestinal microbiota as reservoirs for transmission of antibiotic resistance genes.Pathogens (Basel, Switzerland) · 2014Review
- Integrons: Vehicles and pathways for horizontal dissemination in bacteria.Mobile genetic elements · 2012Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of our study was to compare the presence of the intI1 gene and its associations with the antibiotic resistance of commensal Escherichia coli strains in children with/without previous antibiotic treatments and elderly hospitalized/healthy individuals.
methodsOne-hundred-and-fifteen intestinal E. coli strains were analyzed: 30 strains from 10 antibiotic-naive infants; 27 from 9 antibiotic-treated outpatient infants; 30 from 9 healthy elderly volunteers; and 28 from 9 hospitalized elderly patients. The MIC values of ampicillin, cefuroxime, cefotaxime, gentamicin, ciprofloxacin, and sulfamethoxazole were measured by E-test and IntI1 was detected by PCR.
resultsOut of the 115 strains, 56 (49%) carried class 1 integron genes. Comparing persons without medical interventions, we found in antibiotic-naive children a significantly higher frequency of integron-bearing strains and MIC values than in healthy elderly persons (53% versus 17%; p < 0.01). Evaluating medical interventions, we found a higher resistance and frequency of integrons in strains from hospitalized elderly persons compared with non-hospitalized ones. Children treated with antibiotics had strains with higher MIC values (when compared with antibiotic-naive ones), but the integron-bearing in strains was similar. In most cases, the differences in resistance between the groups (integron-positive and negative strains separately) were higher than the differences between integron-positive and negative strains within the groups.
conclusionThe prevalence of integrons in commensal E. coli strains in persons without previous medical intervention depended on age. The resistance of integron-carrying and non-carrying strains is more dependent on influencing factors (hospitalization and antibiotic administration) in particular groups than merely the presence or absence of integrons.
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